Chemistry of Natural Compounds p. 344 - 349 (1992)
Update date:2022-08-11
Topics:
Ivanov, A. K.
Antonov, A. A.
Donetskii, I. A.
The synthesis has been effected of the amide of the tetrapeptide forming the sequence 6-9 of oxytocin with the use of benzyl protection of the thiol function of cysteine by two main schemes 1+3 and 2+2.The advantageousness of performing the synthesis by the 2+2 scheme has been shown.The overall yield of tetrapeptide using the method of condensation with the formation of mixed anhydrides amounted to 51percent by the scheme proposed.
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(1986)
