An improved reaction of tris(methylthio)methane with epoxides: Application to the efficient synthesis of β-hydroxy esters

Article abstract of DOI:10.1080/00397919308009842

Tris(methylthio)methyllithium reacts efficiently with epoxides in THF:HMPA (5:1) at low temperature to give β-hydroxy orthotrithiocarboxylates which are converted to β-hydroxy esters in high yield.

Full text of DOI:10.1080/00397919308009842

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Synthetic Communications: An
International Journal for Rapid
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Organic Chemistry
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An Improved Reaction of
tris(Methylthio) methane
with Epoxides: Application to
the Efficient Synthesis of β-
Hydroxy Esters
Norman A. Abood a
a Department of Chemistry Searle Research and
Development , Skokie, Illinois, 60077
Published online: 23 Sep 2006.
To cite this article: Norman A. Abood (1993) An Improved Reaction of tris(Methylthio)
methane with Epoxides: Application to the Efficient Synthesis of β-Hydroxy Esters,
Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 23:6, 811-815
To link to this article: http://dx.doi.org/10.1080/00397919308009842
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