Model syntheses of thiazolidine nucleoside analogues

Article abstract of DOI:10.1080/07328319608002037

The syntheses of racemic thiazolidinyl thymine and cytosine derivatives 6a and 6b, and 10a and 10b, prototypes of a novel family of heterosubstituted nucleosides, have been achieved from rhodanine (3) or thiazolidine (7) by a short sequence of steps. The key reaction involved efficient coupling of silylated thymine and cytosine to N-Boc-protected 4- and 5- acetoxythiazolidines, 5 and 9, assisted by tert-butyldimethylsilyl trifluoro- methanesulfonate.

Full text of DOI:10.1080/07328319608002037

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Nucleosides and Nucleotides
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Model Syntheses of Thiazolidine
Nucleoside Analogues
a b
a b
a b
Gloria Rassu
, Franca Zanardi
, Mara Cornia
& Giovanni
a b
Casiraghi
a
Istituto per l'Applicazione delle Tecniche Chimiche Avanzate
del CNR, Via Vienna 2, I-07100, Sassari, Italy
b
Dipartimento Farmaceutico dell'Università, Viale delle Scienze,
I-43100, Parma, Italy
Version of record first published: 15 Aug 2006.
To cite this article: Gloria Rassu , Franca Zanardi , Mara Cornia & Giovanni Casiraghi (1996):
Model Syntheses of Thiazolidine Nucleoside Analogues, Nucleosides and Nucleotides, 15:5,
1113-1120
To link to this article: http://dx.doi.org/10.1080/07328319608002037
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