Copper bromide mediated A-ring dehydrogenation of 19-norsteroids

Article abstract of DOI:10.1080/00397919608003657

A dehydrogenation reaction applied to 19-norsteroids 1a or 1b, with copper(II) bromide in different alcohols yielded estrone alkyl ethers or 13β-ethyl-3-alkoxy gonanes along with products in which the steroid 6-position has been oxidized as aell. Use of small amounts of trialkyl orthoformates in the reaction considerably diminished the overoxidized products.

Full text of DOI:10.1080/00397919608003657

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Copper Bromide Mediated A-
Ring Dehydrogenation of 19-
Norsteroids
Marco Brito a , Elena Campos a , Héctor Salgado
Zamora a & Palmira del Fabbro b
a Departamento de Química Orgánica, Escuela
Nacional Ciencias Biológicas, I.P.N. México,
D.F., 11340, México
b Departamento de Química Orgánica,
Universidad Autonoma del Estado de Morelos,
Cuernavaca, Mor, 62210, México
Published online: 21 Aug 2006.
To cite this article: Marco Brito , Elena Campos , Hctor Salgado Zamora &
Palmira del Fabbro (1996) Copper Bromide Mediated A-Ring Dehydrogenation
of 19-Norsteroids, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 26:3, 623-629, DOI:
10.1080/00397919608003657
To link to this article: http://dx.doi.org/10.1080/00397919608003657
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