Characterization of high molecular weight impurities in synthetic phosphorothioate oligonucleotides

DOI: 10.1016/j.bmcl.2005.10.051

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 607 - 614 (2006)

Update date:2022-08-29

Topics:

Authors:

Kurata, Christine

Bradley, Kym

Gaus, Hans

Luu, Nhuy

Cedillo, Isaiah

Ravikumar, Vasulinga T.

Sooy, Kent Van

McArdle, James V.

Capaldi, Daniel C.

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Article abstract of DOI:10.1016/j.bmcl.2005.10.051

Phosphorothioate oligonucleotides manufactured by standard phosphoramidite techniques using 2′-deoxyadenosine- or 2′-O-(2-methoxyethyl)-5- methylcytosine-loaded solid supports contain branched impurities consisting of two chains linked through the exocycl

Full text of DOI:10.1016/j.bmcl.2005.10.051

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