Synthesis of a 1-benzylpiperazin-2-one nitrone and its reaction with alkynes and alkenes

Article abstract of DOI:10.1016/0040-4039(96)01640-1

A novel 1-benzylpiperazin-2-one nitrone has been synthesized. It readily undergoes [3 + 2] cycloadditions with alkynes and alkenes to give Δ⁴-isoxazolines and isoxazolidines, respectively, which can be reductively opened to 3-substituted piperazin-2-ones and 1,3-amino alcohols.