Highly efficient synthesis of α,β-acetylenic aldehydes from terminal alkynes using DMF as the formylating reagent

Article abstract of DOI:10.1016/S0040-4039(98)01352-5

The formylation of lithium acetylides with DMF led to α,β-acetylenic aldehydes in excellent yields (>94%). A reverse quench into a phosphate buffer (10% aqueous KH₂PO₄,4 equiv) proved to be the key for this high- yielding reaction.