Heterocycles p. 281 - 293 (1999)
Update date:2022-08-18
Topics:
Yoshino, Hiroshi
Koike, Kazuo
Nikaido, Tamotsu
Syntheses of 12H-pyrido[2,1-a]-[β-carbolin-5-ium bromides (15-27) and 11H-pyrrolo[2,1-a]-β-carbolines (32-35), structurally related to the tetracyclic alkaloid javacarboline (1) have been achieved via 2 steps routes starting from the respective β-carbolines. Their synthetic compounds showed potent antitumor activities against P-388 murine leukemia cells and PC-6 human lung carcinoma cells.
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Doi:10.1002/jhet.1710
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(2011)
