Bioorganic and Medicinal Chemistry Letters p. 2033 - 2038 (1998)
Update date:2022-08-30
Topics:
Arlt, Michael
Boettcher, Henning
Riethmueller, Angelika
Schneider, Guenter
Bartoszyk, Gerd D.
Greiner, Hartmut
Seyfried, Christoph A.
SAR for a novel series of dopamine D4 receptor ligands is shown. Very selective, highly potent compounds like 1-(2-pyrimidinyl)-4-(3-(3-thienyl)- benzyl)-piperazine (5f) and 2-(4-(1-fluorenylmethyl)-1-piperazinyl)- pyrimidine (8c) were obtained.
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