5-Halo-6-alkoxy-5,6-dihydro-pyrimidine nucleosides: Antiviral nucleosides or nucleoside prodrugs?

Article abstract of DOI:10.1080/15257779508012413

5-Halo-6-alkoxy-5,6-dihydro derivatives of azidothymidine (AZT) and ethyldeoxyuridine (EDU) were developed and evaluated using in vitro and in vivo models. Although most of these 5,6-dihydro derivatives served as prodrugs in improving site-specific delivery and pharmacokinetic parameters, some unique characteristics were exhibited.

Full text of DOI:10.1080/15257779508012413

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Nucleosides and Nucleotides
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5-Halo-6-alkoxy-5,6-dihydro-pyrimidine
Nucleosides: Antiviral Nucleosides or
Nucleoside Prodrugs?
Leonard. I. Wiebe a , Edward. E. Knaus a , A. Majid Cheraghali a ,
Rakesh Kumar a , Kevin W. Morin a & L. Wang a
a Faculty of Pharmacy and Pharmaceutical Sciences , University of
Alberta , Edmonton, Canada , T6G 2N8
Published online: 16 Feb 2007.
To cite this article: Leonard. I. Wiebe , Edward. E. Knaus , A. Majid Cheraghali , Rakesh Kumar ,
Kevin W. Morin & L. Wang (1995) 5-Halo-6-alkoxy-5,6-dihydro-pyrimidine Nucleosides: Antiviral
Nucleosides or Nucleoside Prodrugs?, Nucleosides and Nucleotides, 14:3-5, 501-505
To link to this article: http://dx.doi.org/10.1080/15257779508012413
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