Synthesis of isotopically labelled versions of adenosine agonist GR79236

Article abstract of DOI:10.1002/(SICI)1099-1344(200001)43:1<11::AID-JLCR286>3.0.CO;2-7

Versions of adenosine receptor agonist GR79236, labelled either with carbon-14 at C-8 of the purine ring or with tritium in the cyclopentyl ring, were prepared in overall yields of 64% and 25% respectively. A mass labelled [M + 4] version containing carbon-13, nitrogen-15, and deuterium was also prepared in 3% yield.