Accumulation of narbonolide by the addition of sodium arsenite

Article abstract of DOI:10.1080/00021369.1974.10861202

Addition of sodium arsenite to the fermentation medium of Streptomyces venezuelae MCRL 0376 caused an inhibition of antibiotic production and a simultaneous accumulation of narbonolide, the aglycone of narbomycin. The accumulation of narbonolide was not observed in the absence of sodium arsenite. The inhibition of antibiotic production by sodium arsenite was not reversed by sodium acetate in contrast to erythromycin fermentation.