Oxidative ortho-C-N fusion of aniline by OsO4. Isolation, characterization of oxo-amido osmium(VI) complexes, and their catalytic activities for oxidative C-C bond cleavage of unsaturated hydrocarbons

Article abstract of DOI:10.1021/ic801352d

In an unusual reaction of osmium(VIII) oxide with p-substituted aromatic amines (X-C₆H₄-NH₂, where X = Me, H, Cl) in heptane afforded the brown osmium(VI)-oxo complexes [OsO(L)₂] (1a-c, L = N-aryl-1,2-arylenediamide) in moderate yields. The ligand L is formed in situ via oxidative ortno-C-N fusion of arylamines. The reaction occurs in an inert atmosphere, and a part of Os(VIII) is used up for the oxidation of aromatic amine. Single crystal X-ray structure of a representative complex 1a is solved. The structural analysis has authenticated the ortno-C-N fusion of ArNH₂ resulting in formation of the diamide ligand, L. The complex as a whole is penta-coordinated, and the coordination sphere has a distorted square pyramidal geometry (τ = 0.26). A similar reaction of osmium(VIII) oxide with the preformed N-phenyl-1,2-phenelene diamine produced the complex 1a in nearly quantitative yield. The substituted phenazine, 5-phenyl-3-phenylimino- 3,5-dihydro-phenazine-2-ylamine, is obtained as a byproduct of the latter reaction. The complexes, 1a-c, can be reduced in a reversible one-electron step, as probed by cyclic voltammetry. The one electron reduced paramagnetic Os(V) intermediate is, however, Electron Paramagnetic Resonance (EPR) silent. Solution spectra of the osmium complexes show several multiple transitions in the UV-vis region. Density functional theory calculations were employed to confirm the structural features and to support the spectroscopic assignments. The complex 1a catalyzes oxidation of a wide variety of unsaturated hydrocarbons like alkenes, alkynes, and aldehydes to the corresponding carboxylic acids in the presence of tert-butylhydroperoxide (TBHP) efficiently at room temperature.

Full text of DOI:10.1021/ic801352d

Inorg. Chem. 2008, 47, 11062-11070
Oxidative ortho-C-N Fusion of Aniline by OsO . Isolation,
4
Characterization of Oxo-Amido Osmium(VI) Complexes, and their
Catalytic Activities for Oxidative C-C Bond Cleavage of Unsaturated
Hydrocarbons
†
Subhas Samanta, Laksmikanta Adak, Ranjan Jana, Golam Mostafa, Heikki M. Tuononen,
‡
‡
§
|
‡
Brindaban C. Ranu, and Sreebrata Goswami*
,†
Department of Inorganic Chemistry and Department of Organic Chemistry, Indian Association for
the CultiVation of Science, Kolkata 700 032, India, Department of Physics, JadaVpur UniVersity,
Kolkata 700 032, India, and Department of Chemistry, UniVersity of JyV a¨ skyl a¨ ,
P.O. Box 35, JyV a¨ skyl a¨ FI-40014, Finland
Received July 19, 2008
In an unusual reaction of osmium(VIII) oxide with p-substituted aromatic amines (X-C
6 4 2
H -NH , where X ) Me, H,
Cl) in heptane afforded the brown osmium(VI)-oxo complexes [OsO(L) ] (1a-c, L ) N-aryl-1,2-arylenediamide) in
2
moderate yields. The ligand L is formed in situ via oxidative ortho-C-N fusion of arylamines. The reaction occurs
in an inert atmosphere, and a part of Os(VIII) is used up for the oxidation of aromatic amine. Single crystal X-ray
structure of a representative complex 1a is solved. The structural analysis has authenticated the ortho-C-N fusion
2
of ArNH resulting in formation of the diamide ligand, L. The complex as a whole is penta-coordinated, and the
coordination sphere has a distorted square pyramidal geometry (τ ) 0.26). A similar reaction of osmium(VIII)
oxide with the preformed N-phenyl-1,2-phenelene diamine produced the complex 1a in nearly quantitative yield.
The substituted phenazine, 5-phenyl-3-phenylimino-3,5-dihydro-phenazine-2-ylamine, is obtained as a byproduct of
the latter reaction. The complexes, 1a-c, can be reduced in a reversible one-electron step, as probed by cyclic
voltammetry. The one electron reduced paramagnetic Os(V) intermediate is, however, Electron Paramagnetic
Resonance (EPR) silent. Solution spectra of the osmium complexes show several multiple transitions in the UV-vis
region. Density functional theory calculations were employed to confirm the structural features and to support the
spectroscopic assignments. The complex 1a catalyzes oxidation of a wide variety of unsaturated hydrocarbons like
alkenes, alkynes, and aldehydes to the corresponding carboxylic acids in the presence of tert-butylhydroperoxide
(TBHP) efficiently at room temperature.
Introduction
bonds. However, to date only a limited number of stable
osmium(VIII) imido species have actually been isolated.
Monoimido osmium(VIII) complexes are accessible directly
4
from OsO with the tertiary alkyl amines in hydrocarbon
8
Organo-imido complexes including those of osmium(VIII)
have been one of the most researched kinds of compounds
primarily because these are potential intermediates
1
-7
for
organic reactions involving the formation of nitrogen-carbon
(2) (a) Berrisford, D. J.; Bolm, C.; Sharpless, K. B. Angew. Chem. 1995,
07, 1159; Angew. Chem., Int. Ed. 1995, 34, 1059. (b) Bruncko, M.;
1
*
To whom correspondence should be addressed. E-mail: icsg@
Khuong, T.-A. V.; Sharpless, K. B. Angew. Chem., Int. Ed. Engl. 1996,
iacs.res.in.
35, 454.
†
Department of Inorganic Chemistry, Indian Association for the
(3) Sharpless, K. B.; Hori, T.; Truesdale, L. K.; Dietrich, C. O. J. Am.
Chem. Soc. 1976, 98, 276.
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99, 3420.
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A.; Nieger, M. Chem.sEur. J. 2003, 9, 5581. (c) Mu n˜ iz, K.; Nieger,
M.; Mansikkam a¨ ki, H. Angew. Chem. 2003, 115, 6141; Angew. Chem.,
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Cultivation of Science.
‡
Department of Organic Chemistry, Indian Association for the Cultiva-
tion of Science.
§
Jadavpur University.
University of Jyv a¨ skyl a¨ .
|
(
1) (a) Nugent, W. A.; Mayer, J. M. Metal Ligand Multiple Bonds; Wiley:
New York, 1988. (b) Wigley, D. E. Prog. Inorg. Chem. 1994, 42,
2
39.
11062 Inorganic Chemistry, Vol. 47, No. 23, 2008
10.1021/ic801352d CCC: $40.75  2008 American Chemical Society
Published on Web 10/31/2008

OxidatiWe ortho-C-N Fusion of Aniline by OsO
4
8-10
solvent or even with aqueous amine solution.
In contrast
Scheme 1
the corresponding reactions with aromatic amines have been
11
confined only to 2,6-disubstituted bulky arylamines. It has
been reported that the similar reaction of unsubstituted aniline
12
4
with OsO leads to degradation together with the formation
of unidentified azo compounds. In this paper we disclose
the synthesis of a family of square pyramidal mono-oxo
diamido osmium(VI) complexes from an unprecedented
4
reaction of OsO and aniline, or its substituted derivatives.
In this reaction the ortho-unsubstituted anilines undergo
oxidative C-N bond fusion to produce doubly deprotonated
N-aryl-1,2-phenylenediamides. Our interest in these reactions
1
7d
osmium-oxo complexes are much weaker oxidants than
the corresponding ruthenium complexes and a suitable
osmium complex catalyst
1
3
originated from our previous results on transition metal
mediated oxidative ortho-C-N fusion of aromatic amines.
The reactions occur because of ortho-C-H activation as a
consequence of metal coordination. Furthermore, we have
1
8-20
for oxidative cleavage of
unsaturated hydrocarbons is scarce in the literature.
Results and Discussion
13a,14,15
shown before
that the cis-coordination of the aromatic
amines is a prerequisite for the above ortho-fusion reaction.
Our work in this area has so far been confined to the use of
Ru(III) and Os(IV) nonoxo compounds as mediators. In this
Synthetic Reaction. Since we are interested in dimeriza-
tion and/or polymerization of aromatic amines by ortho-C-N
bond fusion, we purposefully chose aromatic amines without
any ortho-substitution (like aniline and its para-substituted
4
work OsO was chosen as a mediator since first, it is an
exceptionally strong oxidant, and second, its lability toward
4
derivatives) for the reaction. The reactions of OsO with
8
primary aromatic amines proceeded smoothly in heptane
producing penta-coordinated oxo-amido osmium (VI)
complexes 1a-c as shown in Scheme 1. Isolated yields of
the products after TLC purification were nearly 40%; a
mixture of unidentified brown products also formed along
with 1. We wish to note here that a similar reaction with
substitution by amines is documented in the literature. These
two properties are in fact essential for the above aromatic
amine fusion reactions. The reactions have produced penta-
coordinated mono-oxo osmium(VI) complexes of N-aryl-
diamides as the only major product.
Interestingly the above osmium(VI) oxo complexes are
found to catalyze oxidative cleavage of C-C bonds in
unsaturated hydrocarbons like alkenes and alkynes by
t-butylhydroperoxide at room temperature. Notably, since
2
,6-dichloroaniline failed to produce any identifiable product.
-
The organic reaction, as shown in Scheme 2, involves 2e
oxidation of aromatic amines. Thus, the formation of the bis-
2 4
chelate, 1 (Scheme 1) from 4ArNH and OsO needs a
transfer of a total of four electrons. In comparison, the metal
oxidation level in the product 1 is only two units less than
4
that in the starting compound OsO . The fact that the
1
980s there have been exciting developments in the high
valent ruthenium-oxo complexes, some of which are useful
16,17
and active oxidants
for organic substrates. In comparison,
reference reaction also proceeded smoothly in an inert
atmosphere producing 1 in a similar yield excluded the
possibility of involvement of aerial oxygen in this oxidation
(
7) Donohoe, T. J.; Blades, K.; Moore, P. R.; Waring, M. J.; Winter,
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(
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reaction. Thus, it is anticipated that half of OsO
4
is expended
as oxidant which, in turn, justifies the moderate yields of
(<50%) from the above reactions. For further elucidation
of the above electron accounting issue, a reaction of OsO
(
b) Clifford, A. F.; Kobayashi, C. S. Inorg. Synth. 1960, 6, 207.
21
(
10) Sharpless, K. B.; Patrick, D. W.; Truesdale, L. K.; Biller, S. A. J. Am.
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1
(
4
and the preformed ligand, N-phenyl-1,2-phenylenediamine
1
991, 30, 3595.
(
12) Danopoulos, A. A.; Wilkinson, G.; Hussain-Bates, H.; Hursthouse,
M. B. J. Chem. Soc., Dalton Trans. 1991, 269.
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(18) Che, C.-M.; Cheng, W.-K.; Mak, T. C. W. J. Chem. Soc., Chem.
Commun. 1986, 200.
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1989, 901. (b) Griffith, W. P.; Jollife, J. M. J. Chem. Soc., Dalton
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J. Chem. Soc. Dalton Trans. 1995, 3537.
(
13) (a) Mitra, K. N.; Goswami, S. Inorg. Chem. 1997, 36, 1322. (b) Mitra,
K. N.; Majumdar, P.; Peng, S.-M.; Casti n˜ eiras, A.; Goswami, S. Chem.
Commun. 1997, 1267. (c) Mitra, K. N.; Choudhury, S.; Casti n˜ eiras,
A.; Goswami, S. J. Chem. Soc., Dalton Trans. 1998, 2901. (d) Mitra,
K. N.; Goswami, S. Chem. Commun. 1997, 49. (e) Das, C.; Goswami,
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L. R.; Tom a´ s, M.; Goswami, S. Chem.sEur. J. 2001, 7, 5222.
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Chem. 2003, 42, 198.
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Meyer, T. J. J. Am. Chem. Soc. 1995, 117, 2520. (b) Ho, C.; Che,
C.-M.; Lau, T.-C. J. Chem. Soc., Dalton Trans. 1990, 967. (c) Fung,
W. H.; Yu, W. Y.; Che, C.-M. J. Org. Chem. 1998, 63, 7715. (d)
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Lebeau, E. L.; Binstead, R. A.; Meyer, T. J. J. Am. Chem. Soc. 2001,
(
(
(
(20) Valliant-Saunders, K.; Gunn, E.; Shelton, G. R.; Hrovat, D. A.; Borden,
W. T.; Mayer, J. M. Inorg. Chem. 2007, 46, 5212.
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123, 5594.
1
2
23, 10535. (f) Che, C.-M.; Yip, W.-P.; Yu, W.-Y. Chem. Asian J.
006, 1, 453.
Inorganic Chemistry, Vol. 47, No. 23, 2008 11063

Samanta et al.
Scheme 2
Figure 1. ORTEP representation and atom numbering scheme for [OsO-
a
(
L )2] (1a).
Scheme 3
exactly corroborated with their simulated spectra. Appearance
of strong bands near 3400 and 890 cm in the IR-spectra
-
1
characterize the presence of N-H and OsdO fragments,
1
13
respectively. The NMR spectra ( H as well as C) of the
representative complexes are submitted as Supporting In-
formation, Figure S1 and S2). Notably, the two ligands in
the complexes are magnetically equivalent because of the
presence of a 2-fold rotational symmetry axis (see below),
and hence, resonances for only one ligand were observed.
For example, the complex 1b showed only two methyl proton
resonances at δ 2.55 and 2.30 ppm, respectively. The amide
N-H proton of 1a appeared at δ 4.5 ppm, which exchanges
(
o-semidine) was performed under identical reaction condi-
tions. In this case the isolated yield of 1a was 94%. However,
a higher ligand stiochiometry (OsO : o-semidine ) 1:3) was
4
necessary for completion of the reaction. The excess ligand
used herein brings about the metal reduction Os(VIII) f
Os(VI) at the cost of its self-oxidation
phenylimino-3,5-dihydro-phenazine-2-ylamine (Scheme 3).
The substituted phenazine compound was isolated from the
reaction mixture and characterized. A similar reaction of
1
3
with D
2
O resulting in disappearance of the resonance.
C
2
2,23
NMR and DEPT spectra of the complexes are found to
be informative for their characterization. For instance, the
reactant Ph-NH has only one quaternary carbon, while the
2
to 5-phenyl-3-
DEPT spectrum of the compound 1a indicated the presence
of three such carbon atoms confirming the formation of
o-semidine from aniline via C-N fusion. Similarly, five
quaternary carbon atoms in the 4-substituted compounds 1b
and 1c were observed as expected.
Crystal Structure. Final characterization of the com-
plexes came from the analysis of the X-ray structure of
the representative complex 1a. Suitable crystals for X-ray
structure determination were obtained by slow diffusion
of a dichloromethane solution of the compound 1a into
hexane. The structure analysis of 1a indeed confirmed the
24
OsO
OsVIIIO
It is believed that the reference reaction occurs because
4
with 1,2-diaminobenzene was reported to give trans-
[
2
(opda) ] (opda ) 1,2-diaminobenzene).
2
of induced ortho-C-H activation of a coordinated aryl amido
intermediate. However, there may be several possibilities
which remain unresolved because of the lack of chemical
information of the intermediates. We wish to note here that
such OsO
4
mediated dimerization of aromatic amines is
unknown in the literature. Mayer and co-workers, recently,
have reported
2
1,25
a few examples of nucleophilic aromatic
substitution at the para carbon of a coordinated anilido ligand
in a substitutionally inert Os(IV) complex. We thus conclude
that cis-disposition of the coordinated aryl-amido ligands in
the intermediate complex is possibly the key for the ortho-
C-N fusion reactions.
2
regioselective ortho-fusion of ArNH . Its Oak Ridge
Thermal Ellipsoid Plot (ORTEP) and atom numbering
scheme are depicted in Figure 1. The molecule 1a is penta-
coordinated and the coordination sphere has a distorted
square pyramidal geometry (τ ) 0.26). It is a bis-chelated
Os(VI) complex of N-phenyl-1,2-phenelene diamide ligand
in which the oxide ligand (O1) occupies the fifth position.
A 2-fold rotational axis of symmetry passes through the
OsdO bond with the four basal nitrogen atoms (N1,N2,N1*,
N2*; * ) 1/2 - x, y, 1/2 - z) in an essentially planar
orientation. The osmium atom lies above the plane by
The osmium complexes 1a-c analyzed satisfactorily; their
electrospray ionization mass spectrometry (ESI-MS) spectra
(
(
(
(
22) Chlopek, K.; Bill, E.; Weyherm u¨ ller, T.; Wieghardt, K. Inorg. Chem.
005, 44, 7087.
23) Ghosh, A. K.; Mitra, K. N.; Mostafa, G.; Goswami, S. Eur. J. Inorg.
Chem. 2000, 1961.
24) Danopoulos, A. A.; Wong, A. C. C.; Wilkinson, G.; Hursthouse, M. B.;
Hussain, B. J. Chem. Soc., Dalton Trans. 1990, 315.
25) Soper, J. D.; Saganic, E.; Weinberg, D.; Hrovat, D. A.; Benedict, J. B.;
Kaminsky, W.; Mayer, J. M. Inorg. Chem. 2004, 43, 5804.
2
0
.580 Å toward the oxide ligand. The Os-N bond lengths
are in the range 1.965(21)-1.981(10) Å and the Os-O1
11064 Inorganic Chemistry, Vol. 47, No. 23, 2008

OxidatiWe ortho-C-N Fusion of Aniline by OsO
4
a
Table 2. Cyclic Voltammetry Data of 1a-c
b
b
compound
oxidation E1/2, V
reduction E1/2, V (∆Ep, mV)
c
1
a
0.95
-0.97(75)
-1.08(70)
-0.79(75)
c
1
b
1.01
c
1
c
0.89
a
In dichloromethane solution, supporting electrolyte Bu4NClO4 (0.1 M).
b
E1/2 ) 0.5(Epa + Epc) where Epa and Epc are anodic and cathodic peak
-1
c
potentials respectively. ∆Ep ) Epa - Epc, scan rate 50 mVs
.
Irreversible.
a
Table 3. Absorption Maxima of 1a-c from UV-vis Spectra
-
1
-1
complex
λmax/nm (ε/M cm )
b
b
b
b
1
a
675 , 535(6840), 430 , 350(17285), 295 , 260 , 225(32810)
b
b
b
b
1
b
690 , 555(6245), 445 , 355(17655), 300 , 260 , 230(29955)
b b b b
1
c
680 , 540(5695), 545 , 355(17195), 305 , 260 , 230(29240)
a
b
In CH2Cl2. Shoulder.
Figure 2. Cyclic voltammogram of 1a in CH2Cl2/0.1 M Bu4NClO4.
Table 1. Selected Experimental and Calculated Bond Lengths (Å) and
Angles (deg) of 1a
1
a
exp.
calc.
Os1-O1
Os1-N1
Os1-N2
N1-C1
1.676(13)
1.965(21)
1.981(10)
1.352(24)
1.307(17)
1.380(17)
1.396
1.387
1.389
1.389
1.390
1.721
1.941
1.995
1.376
1.390
1.409
1.390
1.387
1.392
1.387
1.393
114.8
103.8
78.5
N2-C6
N2-C7
Figure 3. UV-vis spectrum of 1a in CH2Cl2.
C1-C2
C2-C3
compound 1a at -1.2 V. The electrogenerated one electron
C3-C4
-
reduced species [1a] was, however, EPR silent. This is
C4-C5
possibly due to high spin orbit coupling constant of Os(V),
C5-C6
5
+
-1
O1-Os1-N1
O1-Os1-N2
N1-Os1-N2
107.1(6)
107.2(3)
77.8(7)
ꢀ(Os ) about 4500 cm . Examples of EPR silent osmi-
27
um(V) complexes are known in the literature. These results
are fully corroborated by density functional theory (DFT)
calculations which show that the lowest unoccupied molec-
ular orbital (LUMO) and highest occupied molecular orbital
bond length is 1.676(13) Å, (see Table 1) indicating its
double bond character.
2
6
(HOMO) of complex 1a are primarily metal and ligand
Cyclic Voltammetry. The redox behavior of the diamido
complexes 1a-c was studied by cyclic voltammetry in
dichloromethane (0.1 M TBAP) in the potential range
between +1.5 and -1.5 V and using a platinum working
electrode. The potentials are referenced to the saturated Ag/
AgCl electrode. The cyclic voltammogram of 1a is displayed
in Figure 2 as an illustrative example. It shows two one-
electron redox processes in the above potential range. A
reversible reductive response appeared near -1.0V; the
second response is irreversible and occurs at an anodic
potential, about +1.0V. The reversible response at the
cathodic potential corresponds to the reduction of the metal
center while the process occurring at the positive potential
formally corresponds to the ligand oxidation. The potentials
of the above couples all vary linearly (Supporting Informa-
centered, respectively (see below). Thus, one electron
reduction of 1a is expected to create an anionic osmium(V)
system with a geometry similar to one observed for the
-
neutral species. DFT optimization carried out for [1a]
revealed only slight elongation (0.04 Å) of the OsdO and
Os-N metrical parameters upon electron attachment which
is in good agreement with the reduction of Os from VI to
V.
UV-vis Spectra and DFT. The compounds 1a-c exhibit
rather similar low-energy absorption spectra with a weaker
band near 680 nm and another near 550 nm (Table 3).
Gaussian analyses of the overlapping bands are shown in
Figure 3. The assignment of these bands is guided by the
results from DFT calculations. Before calculation of the
excitation energies using the time-dependent DFT (TDDFT)
formalism, the molecular structure of 1a was fully optimized
at the BPBE1PBE/TZVP level of theory. The calculated bond
lengths and angles (see data given in Supporting Information,
Table S1) can be compared to the crystallographically
established metrical parameters (Table 1). Overall there is a
very good agreement with the two sets of numbers as bond
p
tion, Figure S3) with respect to the Hammett Σσ parameter
of the substitutions on the ligand. There is quite a large
change in the donor character of the ligand over the above
series of substituents (see Table 2).
One-electron stoichiometry of the reversible process was
confirmed by exhaustive electrolysis of the representative
(
26) Che, C.-M.; Lam, M. H.-W.; Wang, R.-J.; Mak, T. C. W. J. Chem.
Soc., Chem. Commun. 1990, 820.
(27) Dengel, A. C.; Griffith, W. P. Inorg. Chem. 1991, 30, 869.
Inorganic Chemistry, Vol. 47, No. 23, 2008 11065

Samanta et al.
Table 4. Calculated Singlet Transition Energies (> 300 nm) of 1a
Scheme 4
a
symmetry
energy [nm]
dominant contributions (>5%)
a(1)
a(2)
680 (0.0078)
451 (0.0003)
HOMO f LUMO (92%)
HOMO f LUMO+1 (77%)
HOMO-3 f LUMO (17%)
HOMO-3 f LUMO (73%)
HOMO-1 f LUMO+1 (11%)
HOMO-2 f LUMO+2 (8%)
HOMO-4 f LUMO (47%)
HOMO-2 f LUMO+2 (44%)
HOMO-3 f LUMO+1 (83%)
HOMO-4 f LUMO (10%)
HOMO-1 f LUMO (88%)
HOMO-2 f LUMO (8%)
HOMO-2 f LUMO (86%)
HOMO-1 f LUMO+1 (6%)
HOMO-1 f LUMO+1 (86%)
HOMO f LUMO+2 (6%)
HOMO-8 f LUMO (68%)
HOMO f LUMO+2 (19%)
HOMO-5 f LUMO (8%)
HOMO f LUMO+2 (65%)
HOMO-8 f LUMO (16%)
HOMO-1 f LUMO+1 (6%)
HOMO-2 f LUMO+1 (5%)
HOMO-2 f LUMO+1 (81%)
HOMO-1 f LUMO+3 (7%)
HOMO-2 f LUMO+2 (5%)
a(3)
387 (0.0038)
a(4)
a(5)
b(1)
b(2)
b(3)
b(4)
326 (0.0082)
314 (0.0014)
560 (0.0685)
436 (0.0619)
399 (0.0588)
370 (0.0048)
[1a]-Catalyzed Oxidation of Unsaturated Hydro-
carbons. High valent metal-oxo complexes are attractive to
chemists because of their abilities to catalyze the oxidation
of alkenes by formal oxygen atom transfer reaction. Taking
the advantages of the stability of high oxidation state of the
present osmium complexes and their coordinative unsaturated
nature, we set out to explore the possibilities of their
application as catalysts. A representative complex, 1a has
been tested for this purpose. The reference complex indeed
catalyzes oxidation of a wide variety of unsaturated hydro-
carbons like alkenes, alkynes and aldehydes to the corre-
sponding carboxylic acids in the presence of tert-butylhy-
droperoxide (TBHP) with remarkable efficiency at room
temperature. We note here that usually the oxidative
carbon-carbon bond cleavage reactions are achieved either
b(5)
355 (0.1949)
321 (0.0528)
b(6)
a
Oscillator strengths are reported in parenthesis.
28
29,30
by the cumbersome ozonolysis route or by using
4
RuO /
-
NaOCl, RuO
4
/IO
4
, and OsO
4
/oxone reagents. Recently,
lengths and angles are predicted within 2 pm and 1-4° from
the experimental values, respectively. Interestingly, however,
the four basal nitrogen atoms in the 1,2-diamido phenelene
ligands are in a distinctly nonplanar orientation in the
calculated structure though the X-ray analysis showed them
to be in an essentially planar arrangement. This difference
arises most likely from crystallographic packing of the
coplanar N-phenyl groups as such interactions are not
modeled in calculations.
The calculated excitation energies for 1a are reported in
Table 4. The low intensity tail observed in the experimental
spectrum compares well with the calculated value for the
HOMO f LUMO transition at around 680 nm. The two
mid-intensity peaks with transition maxima close to 550 and
3
1
Noyori et al. provided a green synthesis of adipic acid by
the direct oxidation of cyclohexene using aqueous 30% H
in the presence of a catalytic quantity of Na WO and a phase
2 2
O
2
4
transfer catalyst at 75-85 °C. Besides the above-noted metal
oxides only selected examples of dioxo-ruthenium(VI)
complexes are known to catalyze oxidative bond cleavage
17d
reactions. The monooxo-ruthenium(IV) complexes, on the
16
other hand, produce epoxides from olefins. Moreover, the
examples of regioselective C-C bond cleavage of unsatur-
ated hydrocarbons particularly those having less nucleophilic
3
2
character, as in chalcones, are scarce.
Catalytic oxidation of a number of alkenes to carboxylic
acids using non-aqueous t-BuOOH (TBHP) as the terminal
oxidant and OsOL (1a) as the catalyst proceeded cleanly
2
430 nm can be readily assigned to b(1) (HOMO-1 f LUMO)
under homogeneous condition at room temperature. Catalyst
and b(2) (HOMO-2 f LUMO) transitions which are
computationally predicted to appear at 560 and 436 nm,
respectively. Several possible transitions were found to lie
between 300-400 nm. However, calculated oscillator strengths
predict that transitions b(3), b(5), and b(6) should dominate
the spectrum. In fact, the highest oscillator strength is
calculated for the b(5) transition (predominately HOMO f
LUMO+2 in character) at 355 nm which is in excellent
agreement with the experimentally observed band maximum
close to 350 nm.
An analysis of the MOs of the complex 1a reveals that
the highest MOs are centered on the N-phenyl-1,2-phenelene
ligands and are, thus, π-type in character (see Supporting
Figure S4). The lowest unoccupied MOs have significantly
smaller contributions from the two ligands and consist
primarily of p and d orbitals on oxygen and osmium,
respectively. Hence, the transitions given in Table 4 are all
to substrate molar ratios of 0.5-1:100 and excess of TBHP
over the stoichiometric quantity of the oxidant were em-
ployed. The reactions involve C-C bond breaking process
(Scheme 4) yielding carboxylic acids. Pertinent results are
summarized in Tables 5 and 6. Similar reaction using 70%
aqueous TBHP produced the carboxylic acid as the major
product; corresponding 1,2 diols, though in minor quantities
(
28) (a) Bailey, P. S. Chem. ReV. 1958, 58, 925. (b) Criegee, R. Angew.
Chem., Int. Ed. Engl. 1975, 14, 745. (c) Larock, R. C. In Compre-
hensiVe Organic Transformations, 2nd ed.; Wiley-VCH: New York,
1
999; pp 1213-1215. (d) Ogle, R. A.; Schumacher, J. L. Process.
Saf. Prog. 1998, 17, 127. (e) Koike, K.; Inou, G.; Fukuda, T. J. Chem.
Eng. Jpn. 1999, 32, 295.
(
(
(
29) (a) Sica, D. Recent Res. DeV. Org. Chem. 2003, 7, 105. (b) Courtney,
J. L. Organic Synthesis and Oxidation with Metal Compounds; Mijs,
W. J., Cornelis, R. H. I., Eds.; Plenum: New York, 1986; p 445.
30) (a) Travis, B. R.; Narayan, R. S.; Borhan, B. J. Am. Chem. Soc. 2002,
1
24, 3824. (b) Whitehead, D. C.; Travis, B. R.; Borham, B.
Tetrahedron Lett. 2006, 47, 3797.
31) (a) Noyori, R.; Aoki, M.; Sato, K. Chem.Commun. 2003, 1977. (b)
Sato, K.; Aoki, M.; Noyori, R. Science 1998, 281, 1646.
predominantly π
L
f dOs + p
O
type.
(32) (a) Kogan, V.; Quintal, M. M.; Neumann, R. Org. Lett. 2005, 7, 5039.
11066 Inorganic Chemistry, Vol. 47, No. 23, 2008

OxidatiWe ortho-C-N Fusion of Aniline by OsO
4
Table 5. Oxidation of Alkenes by TBHP Catalyzed by 1a
a
TBHP 5.0-6.0 M solution in decane was used. Yields refer to those of purified products characterized by IR, H, 13C NMR spectroscopic data.
b
1
(
5-20%), were also identified as byproducts of these
5, entries 5 and 6) produced benzoic acid in 82% and 78%
yield, respectively. Likewise open chain R-olefins like
1-octene and 1-hexene were easily converted into the
respective alkanoic acids of one less carbon in nearly 80%
yield (Table 5, entries 7 and 8).
reactions. The reactions with 30% hydrogen peroxide,
however, did not show any selectivity. To avoid the
formation of 1,2-diols, the reactions were, in general carried
out using TBHP in moisture free n-decane-acetonitrile
mixture.
As shown in Table 5, a number of aromatic as well as
aliphatic olefins were selectively cleaved by the present
protocol to yield carboxylic acids in high to excellent yields.
Thus, styrene gave an 88% yield of benzoic acid (Table 5,
entry1) and trans-stilbene (Table 5, entry 3) afforded 2 equiv
of benzoic acid within 6 h. However, the R-substituted
aromatic alkene, 1-methyl styrene (Table 5 entry 4) produced
acetophenone in 90% yield. In a similar manner oxidation
of cinnamyl alcohol and trans cinamic acid ethyl ester (Table
Aromatic rings having localized double bond character as
in phenanthrene were also cleaved cleanly under the reaction
protocol affording biphenyl dicarboxilic acid (Table 5, entry
9) in 65% yield. It may be noted here that oxidation of
phenanthrene to corresponding dicarboxylic acid is usually
16f
sluggish. The catalyst is found to be equally effective also
for the oxidation of aromatic alkene with less double bond
character. Thus R,ꢁ-unsaturated chalkones (Table 5, entries
10-13) produced carboxylic acids in high yields. Cyclic
olefins like cyclohexene, cyclooctene, and 1-methyl cyclo-
Inorganic Chemistry, Vol. 47, No. 23, 2008 11067

Samanta et al.
Table 6. Oxidation of Alkynes by TBHP Catalyzed by 1a
a
TBHP 5.0-6.0 M solution in decane was used. Yields refer to those of purified products characterized by IR, H, 13C NMR spectroscopic data.
b
1
Table 7. Oxidation of Aldehyde by TBHP Catalyzed by 1a
a
b
TBHP 5.0-6.0 M solution in decane was used. Yields refer to those of purified products characterized by IR, 1H, 13C NMR spectroscopic data.
hexene also were cleaved affording an 86% yield of adipic
acid, an 82% yield of suberic acid and an 75% yield of 6-oxo
heptanoic acids (Table 5, entries 14-16) respectively.
To exclude the possibility that the complex 1a just serves
was analyzed. ESI-MS of the later mixture indicated rapid
decomposition of the catalyst. In another experiment it was
possible to show that the complex catalyst is stable in styrene.
Thus the results of the above experiments confirm that 1a
acts as a catalyst in bringing about oxidative C-C bond
cleavage of olefins by TBHP.
as a source of OsO
ligands, two following control experiments were planned.
First, a catalytic quantity of OsO was used in place of 1a
4
via the oxidative removal of the diamide
4
Catalytic activities of the osmium compound 1a toward
the cleavage aromatic and aliphatic alkynes were also studied.
Five alkyne substrates were subjected to oxidation, and the
results are summarized in Table 6. Both aromatic and
aliphatic alkynes produced the corresponding carboxylic
acids in high yields (70-85%). Similarly oxidation of
aldehydes was also achieved in high yields (Table 7). Control
experiments were also performed whereby two aldehydes,
namely, benzaldehyde and n-octanal, were reacted separately
with t-butylhydroperoxide without addition of the osmium
catalyst. In these cases only partial oxidation of the aldehydes
to the corresponding carboxylic acids was observed. In
comparison, high yield oxidations (>80%) of the above
aldehydes were achieved in the presence of 1a within 4 h.
for the oxidation of styrene under analogous reaction
conditions as described above. The reaction is unclean and
produced a mixture of products. Working up of the mixture
yielded benzyl alcohol as the major product along with minor
quantities of styrene1,2-diol and benzoic acid. It also
contained small quantities of several unidentified products,
which could not be separated from the crude mixture.
Second, to ascertain the fate of the catalyst after the reaction
we have analyzed the ESI-MS spectrum of the reaction
mixture that contained a catalytic quantity of 1a, styrene,
and t-butylhydroperoxide. A small portion of the mixture
after 7 h stirring was evaporated under vacuum, and the
residue separated by washing with diethyl ether displayed a
peak at m/z, 677 amu in acetonitrile. Its simulation matched
3
3
Similar observation was also noted by others.
+
with a molecular adducts ion [1a.styrene] (Supporting
Information, Figure S6) confirming that the catalyst remained
intact during the reaction. However, after a very prolonged
reaction time (>24 h) the ESI-MS spectrum could not locate
the existence of the catalyst indicating that the catalyst
decomposes in TBHP. This is not unexpected since cyclic
voltammetry of 1a also showed only an irreversible anodic
wave. To confirm it further ESI-MS of a freshly prepared
mixture of the catalyst and TBHP in the absence of styrene
Conclusion
In this work, we have introduced a one pot synthesis of a
family of monooxo osmium(VI) complex (1) of N-aryl
diamide ligand that catalyzes oxidative cleavage of unsatur-
(
33) (a) Mannam, S.; Sekar, G. Tetrahedron Lett. 2008, 49, 1083. (b)
W oˇ jtowicz, H.; Brz a¸ szcz, M.; Kloc, K.; Młochowski, J. Tetrahedron
2001, 57, 9743.
11068 Inorganic Chemistry, Vol. 47, No. 23, 2008

OxidatiWe ortho-C-N Fusion of Aniline by OsO
4
ated hydrocarbons with remarkable efficiency. The synthetic
methodology involved OsO promoted selective ortho-C-N
evaporated under vacuum. The residue was crystallized by slow
evaporation of a dichloromethane-hexane solution mixture. Yield:
4
-1
4
2%. IR (KBr, cm ): 3450 [ν(N-H)], 890 [ν(OsdO)]. ESI-MS,
fusion of aromatic amines. This result is in sharp contrast to
the available literature of such oxidation reactions and has
opened up further the scope of studying aromatic amine
fusion reactions using high valent metal oxides as templates.
For example, it will be of interest to perform the oxidation
+
m/z: 572 [MH] . Anal. Calcd for C24
20 4
H N OsO: C, 50.46; H, 3.52;
N, 9.79 Found: C, 50.51; H, 3.53; N, 9.81.
The substituted complexes 1b and 1c were synthesized similarly
using the appropriate para-substituted anilines in place of aniline.
b
Their yields and characterization data are as follows. OsO(L )
2
(1b).
4
reactions of OsO in neat aromatic amines. Our work in this
-1
Yield: 35%. IR (KBr, cm ): 3400 [ν(N-H)], 890 [ν(OsdO)]. ESI-
area is continuing. The new osmium complexes have been
characterized structurally as well as spectroscopically. Spec-
tral transitions are guided by theoretical studies (DFT). The
complex 1a catalyzes oxidative cleavage of C-C bonds of
a variety of alkenes and alkynes by tert-butylhydroperoxide
in acetonitrile resulting in the formation of the corresponding
carboxylic acids or ketones at room temperature. The
catalytic potential of the osmium complex for the oxidative
bond cleavage of unsaturated hydrocarbons is demonstrated.
+
MS, m/z: 628 [MH] . Anal. Calcd for C28
H
28
N
4
OsO: C, 53.61; H,
c
4
.49; N, 8.90. Found: C, 53.65; H, 4.50; N, 8.91. OsO(L )
2
(1c).
-1
Yield: 40%. IR (KBr, cm ): 3400 [ν(N-H)], 890 [ν(OsdO)]. ESI-
+
4 4
MS, m/z: 709 [MH] . Anal. Calcd for C24H16Cl N OsO: C, 40.65;
H, 2.25; N, 7.86 Found: C, 40.67; H, 2.27; N, 7.90.
a
Reaction of OsO with Preformed HL . To a solution of 0.25 g
4
a
(1.1mmol) of N-phenyl-1,2-phenelenediamine(HL ) in 30 mL of
heptane was added 0.1 g (0.39 mmol) of osmium tetroxide under
dry N atmosphere. The resulting mixture was refluxed for 4 h after
2
which the solution was dried under reduced pressure. The crude
mass, thus obtained, was loaded on a preparative alumina TLC plate
for purification using toluene as the eluent. A red band of 5-phenyl-
3-phenylimino-3,5-dihydro-phenazine-2-ylamine(phenz), which moved
just ahead of the broad reddish brown band, was collected. It was
evaporated to dryness and crystallized from CH Cl -C H solvent
Experimental Section
Instrumentation. UV-vis absorption spectra were recorded on
a Perkin-Elmer Lambda 950 UV/vis spectrophotometer. H and
NMR spectra were taken on a Bruker Advance DPX 300 spec-
trometer. Infrared spectra were obtained using a Perkin-Elmer 783
spectrophotometer. Cyclic voltammetry was carried out in 0.1 M
1
13
C
2
2
6
14
mixture. The characterization data are as follows:
+
Yield: 16%, ESI-MS, m/z: 363[phenzH] . Anal. Calcd for
: C, 79.51; H, 4.98; N, 15.42 Found: C, 79.53; H, 5.01;
N, 15.46.
4 4
[Bu N]ClO solutions using a three-electrode configuration (glassy
24 18 4
C H N
carbon working electrode, Pt counter electrode, Ag/AgCl reference)
and a PC-controlled PAR model 273A electrochemistry system.
The E1/2 for the ferrocenium-ferrocene couple under our experi-
mental condition was 0.39 V. A Perkin-Elmer 240C elemental
analyzer was used to collect microanalytical data (C, H, N). ESI
mass spectra were recorded on a micro mass Q-TOF mass
spectrometer (serial no. YA 263). EPR spectra in the X-band were
recorded with a Bruker System EMX spectrometer. A two-electrode
capillary served to generate intermediates for the X-band EPR
studies.
The second broad brown band was also collected from the TLC
plate. Subsequent evaporation of the solution followed by crystal-
lization by slow diffusion of hexane into the solution of the
compound in dichloromethane yielded a crystalline brown com-
pound, which is identical in all respects to the structurally
characterized sample, 1a. The yield of 1a from the above reaction
was 94%.
Olefin Oxidation. Olefin oxidation reactions were performed
by using a common procedure. A representative example (oxidation
of stilbene) is elaborated below. However, the duration of the
reaction time varied for different substrates as noted in Tables 5
and 6.
To a dry acetonitrile (1.5 mL) solution of stilbene (0.180 g, 1
mmol) was added tert-butylhydroperoxide in decane (1.0 mL) at
room temperature followed by the addition of (0.6 mol %) of the
catalyst 1a. The reaction mixture was allowed to stir for 6.0 h.
The reaction mixture was then extracted with ethyl acetate, washed
4
Materials. The high valent metal oxide OsO was an Aldrich
reagent and the solvents used were obtained from Qualigens and
MERCK (India). N-phenyl-1,2-phenelenediamine was purchased
from Aldrich. Tetrabutylammonium perchlorate (TEAP) was
prepared and recrystallized as reported earlier. All other chemicals
were of reagent grade and used as received. Caution! OsO and
perchlorate salts haVe to be handled with care and with appropriate
safety precautions.
Synthesis. Syntheses of the complexes were carried out by the
reaction of osmium(VIII) oxide with the corresponding anilines in
34
4
2 4
with brine, and dried over Na SO . Evaporation of the solvent under
reduced pressure left the crude product. After column chromatog-
raphy 0.224 g (92%) of pure benzoic acid was isolated. The melting
2
refluxing heptane. The complexes 1 (general formula OsOL ) were
obtained as the major products along with some unidentified minor
products which are not considered here.
1
13
point and spectroscopic data (IR, H and C NMR) of the products
were in good agreement with those of an authentic sample of
benzoic acid.
a
Syntheses of OsOL
mmol) of OsO
refluxed for 4 h in dry N
2
. OsO(L )
2
(1a): A mixture of 1 g (3.94
4
, and 1.49 g (16 mmol) of aniline in heptane was
atmosphere. During this period the color
The above procedure was also followed for the oxidations of
alkynes and aldehydes.
2
of the solution changed from red to dark brown. The crude mass
thus obtained by evaporation of the solvent was dissolved in a
minimum volume of dichloromethane and loaded on a preparative
alumina TLC plate for purification. Toluene was used as the eluent.
A broad reddish brown zone was collected, and the solvent was
Crystallography. Crystallographic data of the compound 1a are
collected in Table 8. Suitable X-ray quality crystals of 1a were
obtained by slow evaporation of a dichloromethane-hexane solution
of the compound. All data were collected on a Bruker SMART
APEX diffractometer, equipped with graphite monochromated Mo
KR radiation (λ ) 0.71073 Å) and were corrected for Lorentz-
polarization effects. A total of 6343 reflections were collected, out
of which 2514 were unique (Rint ) 0.0401), satisfying the (I >
2σ(I)) criterion, and were used in subsequent analysis.
(
(
34) Goswami, S.; Mukherjee, R. N.; Chakravarty, A. Inorg. Chem. 1983,
2, 2825.
35) (a) Sheldrick, G. M. Acta Crystallogr., Sect. A 1990, 46, 467. (b)
Sheldrick, G. M., SHELXL 97. Program for the refinement of crystal
structures; University of G o¨ ttingen; G o¨ ttingen, Germany, 1997.
2
Inorganic Chemistry, Vol. 47, No. 23, 2008 11069

Samanta et al.
Table 8. Crystallographic Data of 1a
corresponding effective core potential (ECP) basis set of similar
valence quality was used. Electronic excitation energies of 1a
3
7
1
a
were calculated using time-dependent density functional formalism
empirical formula
molecular mass
temperature (K)
crystal system
space group
a (Å)
b (Å)
c (Å)
R(deg)
C24H20N4OsO
570.68
293(2)
monoclinic
P2/n
14.036(2)
4.9270(9)
14.698(3)
90
95.070(3)
90
1012.5(3)
2
(TDDFT) utilizing the same functional-basis set combination which
was used in the geometry optimization. All calculations were
3
8
performed with the Turbomole 5.9.1 program package.
Acknowledgment. Financial support from the Department
of Science and Technology (DST)(Project SR/S1/IC-24/
2
006) New Delhi, is gratefully acknowledged. S.S. thanks
ꢁ
(deg)
the Council of Scientific and Industrial Research, New Delhi
for his fellowship. Crystallography was performed at the
DST-funded National Single Crystal Diffractometer Facility
at the Department of Inorganic Chemistry, IACS. Thanks
are due to Professor Wolfgang Kaim and Dr. Biprajit Sarkar
for EPR measurements. H.M.T. thanks the Academy of
Finland and the University of Jyv a¨ skyl a¨ for their generous
financial support. We are thankful to the reviewers for their
constructive suggestion at the revision stage.
γ(deg)
3
V (Å )
Z
3
Dcalcd (g/cm )
1.872
cryst. dimens. (mm)
θ range for data coll (deg)
GOF
0.12 × 0.16 × 0.32
2.8-28.4
1.144
6343
2514
1.44, -1.35
R1 ) 0.0393
wR2 ) 0.0893
reflns. collected
unique reflns.
largest diff. between peak and hole (e Å-3)
final R indices [I > 2σ(I)]
The structure was solved by employing the SHELXS-97 program
Supporting Information Available: X-ray crystallographic files
3
5a
2
1
13
package
and refined by full-matrix least-squares based on F
in CIF format for 1a; figures of H NMR spectra of 1a (S1); C NMR
spectra of 1b (S2), Hammett’s plot (S3), selected orbital isosurfaces
of 1a (S4), ORTEP and atom numbering scheme of 1a (S5) are
3
5b
(
SHELXL-97). During refinement, the N-phenyl 1,2-phenelene
diamide ligand was found to be disordered (Supporting Information,
Figure S5) over two orientations (N1, C1, C2, C3, C4, C5, C6,
C7, C8, C9, C10, C11, C12 and N1′, C1′, C2′, C3′, C4′, C5′, C6′,
C7′, C8′, C9′, C10′, C11′, C12′) with 0.5:0.5 occupancy ratio. The
final refinement was done with SHELX restraints SIMU for
disordered ligands and ISOR for N1, N1′ and N2. The final
difference Fourier map does not show any chemically significant
peak. All hydrogen atoms were added in calculated positions. All
aromatic rings were fitted and refined as regular hexagon.
+
provided and ESI-MS spectrum of [1a.styrene] (S6). This material
is available free of charge via the Internet at http://pubs.acs.org.
IC801352D
(
36) (a) Perdew, J. P.; Burke, K.; Ernzerhof, M. Phys. ReV. Lett. 1996, 77,
3
865. (b) Perdew, J. P.; Burke, K.; Ernzerhof, M. Phys. ReV. Lett.
1997, 78, 1396. (c) Perdew, J. P.; Ernzerhof, M.; Burke, K. J. Chem.
Phys. 1996, 105, 9982. (d) Ernzerhof, M.; Scuseria, G. E. J. Chem.
Phys. 1999, 110, 5029.
Computational Details. Density functional theory (DFT) cal-
(
37) (a) Schaefer, A.; Horn, H.; Ahlrichs, R. J. Chem. Phys. 1992, 97, 2571.
(b) Schaefer, A.; Huber, C.; Ahlrichs, R. J. Chem. Phys. 1994, 100,
5829.
38) TURBOMOLE, Program Package for ab initio Electronic Structure
Calculations, Version 5.9.1; University of Karlsruhe: Karlsruhe,
Germany, 2007. (b) Ahlrichs, R.; B a¨ r, M.; H a¨ ser, M.; Horn, H.;
K o¨ lmel, C. Chem. Phys. Lett. 1989, 162, 165.
culations were performed for the C
compound 1a and its reduced anionic form [1a] . The calculations
2
symmetric Os(VI) oxo-
-
(
utilized a combination of the hybrid PBE1PBE exchange-correlation
3
6
functional with Ahlrichs’ triple-ꢂ valence basis sets augmented
by one set of polarization functions (def-TZVP); for osmium, the
11070 Inorganic Chemistry, Vol. 47, No. 23, 2008