α-Chymotrypsin-catalyzed (3 + 7) segment synthesis of the luteinizing hormone releasing hormone

Article abstract of DOI:10.1016/S0040-4039(00)78861-7

The formation of the luteinizing hormone releasing hormone (LHRH) Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂ (1), from the segments Glp-His-Trp-OEt (2) and H-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂ (3) is catalyzed by α-chymotrypsin. A yield of 71% was achieved when the reaction was performed at -15°C in a solution which contained 38 vol% DMSO and was saturated with KCl.