An expedient route to the tetrazole analogues of α-amino acids

DOI: 10.1021/ol020096x

Source and publish data:

Organic Letters p. 2525 - 2527 (2002)

Update date:2022-08-16

Topics:

Authors:

Demko, Zachary P.

Sharpless, K. Barry

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Article abstract of DOI:10.1021/ol020096x

(Matrix presented) Convenient conditions are described for the transformation of α-aminonitriles to the tetrazole analogues of α-amino acids. Refluxing the starting material in water/2-propanol at 80 °C with sodium azide and catalytic zinc bromide affords

Full text of DOI:10.1021/ol020096x

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