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3
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3. Conclusion
In conclusion, we have demonstrated a successful and simple
protocol for a multicomponent coupling reaction involving
azomethine ylide dipolar cycloaddition chemistry from
dihydroquinoxalinone 1 and a variety of aldehydes. The scope of
the dipolarophile needs further study but the chemistry allows
access to novel heterocyclic products as single stereoisomers.
The strategy provides a way to prepare libraries of compounds
based on the pyrroloquinoxalinone core for biological screening.
4. Acknowledgments
We acknowledge support from the EPSRC and the University
of Sheffield. We thank Craig Robertson for the single crystal X-
ray analysis, Sandra van Meurs and Craig Robertson for help
with NMR spectroscopy, and the Faculty of Science mass
spectrometry service.
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