Journal of the Chemical Society. Perkin transactions I p. 3196 - 3204 (1981)
Update date:2022-08-11
Topics:
Blackburn, G. Michael
Flavell, Andrew J.
Orgee, Lawrence
Will, James P.
Williams, Gillian M.
Syntheses are described for the preparation of <9(10)-(3)H>anthracene, <6-(3)H>benzopyrene, and <7-Me-(3)H1>-7,12-dimethylbenzanthracene.The nature and extent of covalent binding of these hydrocarbons to calf thymus DNA resulting from ultraviolet or gamma irradiation, from oxidative processes involving iodine or hydrogen peroxide, or from oxygen in conjunction with NADPH and a rat liver microsomal preparation is investigated.The displacement of tritium on hydrocarbon bonding to DNA identifies position-6 in benzopyrene and position-9 in anthracene as sites for DNA binding by irradiation processes or by chemical oxidation.Metabolic binding of benzopyrene to DNA shows an altered regioselectivity while that for 7,12-dimethylbenzanthracene appears to involve the 7-methyl group.
View MoreNantong Baokai Chemical Co., Ltd (Hangzhou Baokai Bio-Chemicals Co.,Ltd.)
Contact:+86-513-83886111
Address:No. 68 Suzhou road ,Binjiang Fine Chemical Industrial Park , Beixin town, Qidong city ,Jiangsu province
Contact:+86-10-67147360/67107388
Address:No.18 Guangming Zhongjie, Chongwen District, Beijing, 100061, China
QINGDAO NEW FLOURISH INTERNATIOANAL TRADE CO., LTD.
Contact:+86 532 80861829
Address:No. 1, Yinchuan East Road, 266061, Qingdao, China
Taizhou Elitechemie MediPharma Technology Co.,Ltd.
Contact:+86-523-86810021
Address:Building G14,NO.1 Avenue,China Medical City, Taizhou, Jiangsu,China
Hubei Lingsheng Pharmaceuticals Co., Ltd.
Contact:+86-0710-3538058
Address:Xiangyang City Xiangcheng Economic Development Zone, Hubei Province
Doi:10.1246/bcsj.55.3770
(1982)Doi:10.1021/ol902131n
(2009)Doi:10.1021/jo048940f
(2004)Doi:10.1021/jo00278a026
(1989)Doi:10.1021/jo00119a055
(1995)Doi:10.1016/j.bioorg.2021.104954
(2021)
