Chemistry of Natural Compounds p. 1076 - 1079 (2019)
Update date:2022-08-10
Topics:
Chen, Jia
Yang, Xu
Li, Bo
Yang, Kun
Wang, Yiqin
Sun, Kexing
Zhang, Yong
Zhu, Weiliang
A novel glucoside sesquiterpenoid (1) was isolated from Chrysanthemum indicum L. flowers, together with 14 known compounds (2–15), among which eight compounds (3, 4, 8, and 10–14) were isolated from the plant for the first time. Their structures were determined on the basis of the interpretation of spectroscopic data, viz., ESI-MS, HR-TOF-MS, IR, and NMR. The effects of these compounds onlipopolysaccharide-induced nitric oxide production by RAW 264.7 cells were investigated. Compounds 2, 3, and 7 showed strong or moderate inhibitory effects at 100 μM, and the IC50 values of 3 and 7 were 36.09 and 9.59 μM, respectively.
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