PF1163A and B, new antifungal antibiotics produced by Penicilium sp. II. Physico-chemical properties and structure elucidation

Article abstract of DOI:10.7164/antibiotics.53.38

The structures of new antifungal antibiotics, PF1163A and B, were elucidated by spectroscopic analyses of the degradation products and by X-ray crystallography of the de-2-hydroxyethyl derivative of PF1163B. Both antibiotics consist:of a 13-membered macrocyclic structure containing a derivative of N-methyl tyrosine and a hydroxy fatty acid. PF1163A differs from PF1163B by having an additional hydroxyl group on the side chain.