Mechanism of 1,2ꢀdialkyldiaziridine formation
Russ.Chem.Bull., Int.Ed., Vol. 61, No. 6, June, 2012
1127
Further the absorbance was measured at an interval of 15—20 s
for the subsequent 1—3 min and then at an interval of 0.5—2 min
until the zero absorbance of the sample was attained. Diaziriꢀ
dines were isolated as follows: an undiluted reaction mixture was
saturated with NaOH, and the upper layer was separated and
dried above NaOH. Diaziridines were distilled above NaOH
under atmospheric pressure collecting the fraction with b.p.
V. V. Kachala, Yu. V. Nelyubina, K. A. Lyssenko, N. N.
Makhova, Mendeleev Commun., 2009, 19, 276; (f) Yu. S.
Syroeshkinа, V. V. Kuznetsov, V. V. Kachala, N. N. Makhoꢀ
va, J. Heterocycl. Chem., 2009, 46, 1195.
4. (а) Сh. J. Paget, Ch. S. Davis, J. Med. Chem., 1964, 7, 626;
(b) L. I. Khmel´nitskii, N. N. Makhova, O. V. Lebedev,
L. V. Epishina, L. I. Suvorova, Tez. Dokl. II S"ezda farmatꢀ
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O. G. Nabiev, S. N. Denisenko, S. A. Sukhanova, E. F.
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4
8—50 C for 1,2ꢀdimethyldiaziridine (1а) and the fraction with
b.p. 98—100 C for 1,2ꢀdiethyldiaziridine (1b). The obtained
physicochemical characteristics for 1,2ꢀdimethyldiaziridine (1а)
almost coincided with those given in refs 6 and 14 and for 1,2ꢀdiꢀ
ethyldiaziridine (1b) they coincided with those published
earlier.1
d,6
The calculated and experimental data were compared by the
"
corr" functions incorporated into the Mathcadꢀ14 system.
5
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[
oeshkinа, I. V. Ovchinnicov, V. V. Kuznetsov, V. V. Kachaꢀ
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Received October 24, 2011;
(
е) Yu. S. Syroeshkinа, I. V. Ovchinnichov, V. V. Kuznetsov,
in revised form March 15, 2012