Journal of Antibiotics p. 245 - 255 (1999)
Update date:2022-08-17
Topics:
Qian-Cutrone, Jingfang
Ueki
Huang, Stella
Mookhtiar, Kasim A.
Ezekiel, Regina
Kalinowski, Steven S.
Brown, Karen S.
Golik, Jerzy
Lowe, Susan
Pirnik, Dolores M.
Hugill, Robert
Veitch, Judy A.
Klohr, Steven E.
Whitney, Jeffrey L.
Manly, Susan P.
During the screening of the natural products for their ability to increase the activity of glucokinase by relieving inhibition by long chain fatty acyl CoA esters (FAC), two novel compounds, glucolipsin A (1) and B (2) were isolated from the butanol extracts of Streptomyces purpurogeniscleroticus WC71634 and Nocardia vaccinii WC65712, respectively. The structures of these two compounds were established by spectroscopic methods and chemical degradation. Glucolipsin A (1) and B (2) relieved the inhibition of glucokinase by FAC with RC50 values of 5.4 and 4.6 μM.
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