A PRACTICAL PROCESS FOR LARGE-SCALE SYNTHESIS OF (S)-5-HYDROXY-6-TRANS-8,11,14-CIS-EICOSATETRAENOIC ACID (5-HETE)

DOI: 10.1016/0040-4039(81)80080-9

Source and publish data:

Tetrahedron Letters p. 299 - 302 (1981)

Update date:2022-08-30

Topics:

Authors:

Corey, E. J.

Hashimoto, Shun-ichi

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Article abstract of DOI:10.1016/0040-4039(81)80080-9

(S)-5-hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid (5-HETE) (1) and its enantiomer are readily available by a chemical synthesis from arachidonic acid which includes a chromatographic separation of diastereomeric urethanes (3) made from (+/-)-5-HETE methyl ester and the isocyanate 4 derived from dehydroabietylamine.

Full text of DOI:10.1016/0040-4039(81)80080-9

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