The synthesis and P388 cytotoxicity of mycalazol 11 and related 5-acyl- 2-hydroxymethylpyrroles

Article abstract of DOI:10.1016/S0960-894X(99)00021-9

We report a general method for the synthesis of mycalazol 11 and some mimed 5-acyl-2-hydroxymethylpyrroles using a Stille coupling of 5-(tri-n- butylstannyl)pyrrole-2-carboxaldehyde with an acid chloride as the key step. The newly prepared 5-acyl-2-hydroxymethylpyrroles 5-7, together with the 5- carboxamido-2-hydroxymethylpyrrole 10, have been assayed for in vitro cytotoxicity against the P388 murine leukemia cell line.