European Journal of Medicinal Chemistry p. 889 - 894 (1996)
Update date:2022-08-16
Topics:
Pujol
Rosell
Guillaumet
The synthesis of new series of spiropiperidines is reported. Some of these compounds showed interesting adrenergic activity. The biological activities of the new compounds were evaluated on-guinea pig atria (pi), guinea-pig trachea (β2) and rat vas deferens (a). Compounds 6a, 6c and 6f showed activity comparable to propranolol, in spite of being tertiary amines.
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