Design of the synthesis of steroidal 1,3,5(10),9(11)-tetraenes via isomerization of 1,3,5(10),8-isomers - Effect of the solvent system

Article abstract of DOI:10.1080/00397919608003846

p-Toluenesulphonic acid catalytic isomerization of 1,3,5(10),8-tetraene steroids in benzene or toluene with the presence of acetic acid is established as a simple high-yield (85 ~ 89%) procedure to the synthesis of the corresponding 9(11)-isomers. The solvation effect is discussed for the design of the new reaction media.

Full text of DOI:10.1080/00397919608003846

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Synthetic Communications: An
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Design of the Synthesis of
Steroidal 1,3,5(10),9(11)-
Tetraenes via Isomerization of
1,3,5(10),8-Isomers - effect of
the Solvent System
a
a
b
Li-Gong Liu , Tong Zhang & Zhen-Su Li
a
Department of Chemistry , Central Queensland
University , Rockhampton, Queensland, Australia ,
4
702
b
School of Pharmaceutical Sciences, Beijing Medical
University , Beijing, 100083, P. R. China
Published online: 23 Aug 2006.
To cite this article: Li-Gong Liu , Tong Zhang & Zhen-Su Li (1996) Design of the
Synthesis of Steroidal 1,3,5(10),9(11)-Tetraenes via Isomerization of 1,3,5(10),8-
Isomers - effect of the Solvent System, Synthetic Communications: An International
Journal for Rapid Communication of Synthetic Organic Chemistry, 26:23, 4437-4446,
DOI: 10.1080/00397919608003846
To link to this article: http://dx.doi.org/10.1080/00397919608003846
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