Journal of Pharmaceutical Sciences p. 92 - 93 (1980)
Update date:2022-08-29
Topics:
Wolf
Zimmerman
A simultaneous assay for the detection of clofibrate and its metabolite, clofibric acid [2-(p-chlorophenoxy)-2-methylpropionic acid], is described. This GLC method is rapid and does not require a derivatization step. It is sensitive to 1-μg/ml levels of either compound in biological samples and can be used to characterize the in vivo conversion of clofibrate ester to the free acid.
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