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Indole

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Name

Indole

EINECS 204-420-7
CAS No. 120-72-9 Density 1.22 g/cm3
Solubility methanol: 0.1 g/mL, clear Melting Point 51-54 °C(lit.)
Formula C8H7N Boiling Point 253 °C at 760 mmHg
Molecular Weight 117.16 Flash Point 107.839 °C
Transport Information UN 2811 6.1/PG 3 Appearance white crystals with an unpleasant odour
Safety 26-36/37/39-60-61-45-36/37 Risk Codes 21/22-37/38-41-50/53-36-39/23/24/25-23/24/25
Molecular Structure Molecular Structure of 120-72-9 (Indole) Hazard Symbols HarmfulXn,DangerousN,ToxicT
Synonyms

2,3-Benzopyrrole;1-Benzo(b)pyrrole;1H-indole;1-Azaindene;Benzopyrrole;2, 3-Benzopyrrole;Indole 99%min;Indole perfume;Indole industrial;Indole Crystal;1-Benzazole;2,3-Benzopyrole;Ketole;Benzo[b]pyrrole;3-benzopyrrole; 1H-indole;

 

Indole Chemical Properties

Molecular Structure:

Molecular Formula: C8H7N
Molecular Weight: 117.1479
IUPAC Name: 1H-Indole
Synonyms of Indole (CAS NO.120-72-9): 1-Azaindene ; 1-Benzazole ; 1-Benzo(b)pyrrole ; 1H-Indole ; 2,3-Benzopyrole ; 2,3-Benzopyrrole ; AI3-01540 ; Benzopyrrole ; CCRIS 4421 ; Caswell No. 498B ; EINECS 204-420-7 ; EPA Pesticide Chemical Code 025000 ; FEMA No. 2593 ; HSDB 599 ; INDOLE ; Indol [German] ; Indole (natural) ; Ketole ; NSC 1964 ; UNII-8724FJW4M5
CAS NO: 120-72-9
Classification Code: Skin / Eye Irritant ; Tumor data 
Density: 1.22g/cm3
Melting Point: 51-54oC
Boiling Point: 253-254oC
Flash Point: 136oC
Solubility: 2.80 g/L (25oC)
Appearance: white crystals with an unpleasant odour
Mol File: 120-72-9.mol
storage temp.: 2-8oC
Sensitive: Light Sensitive
BRN:107693

Indole History

  Indole (CAS NO.120-72-9) can be used to produce isatin and oxindole. Oxindole was  reduced  to indole using zinc dust by Adolf von Baeyer In 1866. Then in 1869, Adolf von Baeyer give a formula for indole.Until the end of the 19th century,one kind of indole derivatives was important dyestuffs. Later, In the 1930s, people found that the indole nucleus is present in many important alkaloids.  It plays an important role in today research work.

Indole Uses

  Indole (CAS NO.120-72-9) is used in Natural jasmine oil. Natural jasmine oil is used in the perfume industry which contains about 2.5% of indole. Besides,Indole is used in the manufacture of synthetic jasmine oil.

Indole Production

Method of synthesis of Indole (CAS NO.120-72-9): Leimgruber-Batcho indole synthesis; Fischer indole synthesis; Bartoli indole synthesis; Bischler-M?hlau indole synthesis; Fukuyama indole synthesis; Gassman indole synthesis; Hemetsberger indole synthesis; Larock indole synthesis; Madelung synthesis; Nenitzescu indole synthesis; Reissert indole synthesis; Baeyer-Emmerling indole synthesis

Indole Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 117mg/kg (117mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 94, Pg. 1620, 1974.
mouse LD50 subcutaneous 225mg/kg (225mg/kg)   Klinische Wochenscrift. Vol. 35, Pg. 504, 1957.
mouse LDLo oral 1070mg/kg (1070mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 14, Pg. 111, 1985.
rabbit LD50 skin 790mg/kg (790mg/kg)   American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.
rat LD50 oral 1gm/kg (1000mg/kg)   American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.

Indole Consensus Reports

Reported in EPA TSCA Inventory.

Indole Safety Profile

A poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion and skin contact. A severe eye irritant. Questionable carcinogen with experimental carcinogenic and tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.
Safty informations about Indole (CAS NO.120-72-9):
Hazard Codes: XiIrritant,NDangerous,TToxic
Risk Statements:21/22-37/38-41-50/53-36-39-23/24/25 
R21/22: Harmful in contact with skin and if swallowed. 
R37/38: Irritating to respiratory system and skin. 
R41: Risk of serious damage to the eyes. 
R50/53: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 
R36: Irritating to eyes. 
R39: Danger of very serious irreversible effects. 
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements:26-36/37/39-60-61-45 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection. 
S60: This material and its container must be disposed of as hazardous waste. 
S61: Avoid release to the environment. Refer to special instructions / safety data sheets. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 1
RIDADR: UN 2811 6.1/PG 3
RTECS: NL2450000
F: 8-13
HazardClass: 9
PackingGroup: III

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