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Naproxen sodium

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Name

Naproxen sodium

EINECS 247-486-2
CAS No. 26159-34-2 Density ==
Solubility Melting Point 250-251 °C
Formula C14H13O3.Na Boiling Point 403.9 °C at 760 mmHg
Molecular Weight 252.25 Flash Point 154.5 °C
Transport Information Appearance white powder
Safety Risk Codes 22
Molecular Structure Molecular Structure of 26159-34-2 (Naproxen sodium) Hazard Symbols HarmfulXn
Synonyms

2-Naphthaleneaceticacid, 6-methoxy-a-methyl-, sodiumsalt, (S)-;2-Naphthaleneacetic acid, 6-methoxy-a-methyl-, sodium salt, L-(-)- (8CI);(2S)-2-(6-Methoxy-2-naphthyl)propanoic acid sodium salt;Aflaxen;Agilxen;Aleve;Anaprox;Anaprox DS;Apranax;Apraxin;Dafloxen;Duk-F;Flanax;Flanax Forte;Gynestrel;Lefaine;Licorax;Miranax;Naprelan;Naprogesic;

 

Naproxen sodium Specification

The Naproxen sodium, with the CAS registry number 26159-34-2, is also known as 2-Naphthaleneacetic acid,6-methoxy-alpha-methyl-,sodium salt,(S)-. It belongs to the product categories of Essential Chemicals;Reagent Grade;Routine Reagents.Its EINECS number is 247-486-2. This chemical's molecular formula is C14H13NaO3 and molecular weight is 252.24.What's more,Its systematic name is Sodium (-)-2-(6-methoxy-2-naphthyl)propionate.It is an anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.

Physical properties about Midazolam are:
(1)ACD/LogP:  2.998; (2)# of Rule of 5 Violations:  0; (3)#H bond acceptors:  3; (4)#H bond donors:  1; (5)#Freely Rotating Bonds:  3; (6)Flash Point:  154.5 °C; (7)Enthalpy of Vaporization:  69.1 kJ/mol; (8)Boiling Point:  403.9 °C at 760 mmHg; (9)Vapour Pressure:  3.01E-07 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:[Na+].[O-]C(=O)[C@H](c1ccc2c(c1)ccc(OC)c2)C;
(2)Std. InChI:InChI=1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1;
(3)Std. InChIKey:CDBRNDSHEYLDJV-FVGYRXGTSA-M.

The toxicity data of Midazolam as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 600mg/kg/30D- (600mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS
American Journal of Diseases of Children. Vol. 142, Pg. 524, 1988.

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