Therapeutic index (TI)

Synthesis QSAR (quantitative structure-activity relationship) Heterocyclic compounds Molecular docking Esterification Pharmacophore Cytotoxicity binding affinity antimicrobial agents Minimum inhibitory concentration (MIC) Analogues Enzyme inhibition In vitro Testing In Vivo Testing Biological Evaluation Lead Optimization Zone of Inhibition Virtual Screening Resistance Structure-Activity Relationship (SAR) Antiviral Activity Enzyme Kinetics Coumarin Drug Resistance Drug Repurposing Chirality MIC Determination Bioavailability Mycobacterium tuberculosis In Silico Studies Antitubercular Agents Metabolic Stability Antifungal Activity Scaffold Hopping Toxicity Profile Bioisosteres In vitro assay Anti-HIV activity Quinazolinones Docking simulation Gram-positive bacteria Gram-negative bacteria MIC assay Drug-likeness Antibacterial spectrum ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) Pharmacokinetics (PK) Chromatography (e MTT assay IC?? (Half-maximal inhibitory concentration)