Anti-AIDS agents - XXVIII. Synthesis and anti-HIV activity of methoxy substitute 3',4'-di-O-(-)-Camphanoyl-(+)-cis-Khellactone (DCK) analogues

DOI: 10.1016/S0960-894X(97)10050-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2573 - 2578 (1997)

Update date:2022-07-29

Topics: Synthesis Esterification Analogues Structure-Activity Relationship (SAR) Coumarin Chirality In vitro assay Anti-HIV activity Chromatography (e MTT assay IC?? (Half-maximal inhibitory concentration) Spectroscopy (e Therapeutic index (TI)

Authors:

Takeuchi, Yasuo

Xie, Lan

Cosentino, L. Mark

Lee, Kuo-Hsiung

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)10050-6

Four isomeric methoxy substituted DCK analogues (3-6) were asymmetrically synthesized from different starting materials. 5-Methoxy-3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (5) exhibited extremely potent anti-HIV activity against HIV-1 replication in H9 lymphocyte cells with EC₅₀ and therapeutic index values of 0.00038 μM and >402,632, respectively, which are better than those of DCK and AZT in this assay.

Full text of DOI:10.1016/S0960-894X(97)10050-6

Products guided by the article

Product name:3-methoxyseselin

Cas No:199393-47-0

R&D Labs maybe for 199393-47-0

Linyi VIHO Chemical Co.,Ltd

Contact:86-15588110016

Address:LINYI CITY,SHANDONG PROVINCE,CHINA
WD Silicone Co., Ltd

Contact:+86-27-87204219, +86-27-87215023

Address:2402, HuiGu Space-time Building, 8 Forest Road, East Lake Hi-Tech Development Zone
Zhejiang Hoshine Silicon Industry Co., Ltd.

Contact:86-573-89179966

Address:Zhapu Town, Pinghu City, Zhejiang, China
Kunshan Yalong Trading Co,.Ltd

Contact:86-512-57621185

Address:805-807 Room Hongqiao Mansion ,1088 West Qianjin Road, Kunshan, Jiangsu，China
Zhongshan Haihong Medicine Co., Ltd.

Contact:86-0760-86925778 （0）18824993998

Address:A7 building,lianyuan road Torch Hi-tech Industrial Development Zone

Relevant to this article

Synthesis of New Nucleosides by Coupling of Chloropurines with 2- and 3-Deoxy Derivatives of N-Methyl-D-ribofuranuronamide

Doi:10.1002/hlca.19980810113
(1998)
Synthesis of 1,2,4-triazole-fused heterocycles by tandem appel dehydration/thermal rearrangement methodology

Doi:10.1055/s-1997-1380
(1997)
CYCLOPENTANATION WITH β-METHYLTHIO-ALLYL PHENYL SULFONE

Doi:10.1016/S0040-4039(00)96860-6
(1987)
Tripod ligands of constitutional C₁ symmetry containing a deliberate set of mixed P/S donor groups: Synthesis and coordination chemistry

Doi:10.1016/S0020-1693(97)05784-8
(1998)
Intramolecular Diels-Alder reaction of dinitro-olefin derivatives of furan for the preparation of a versatile tool: 3,7-Dinitro-11- oxatricycloundec-9-ene

Doi:10.1016/S0040-4020(97)10411-2
(1998)
Et₃N mediated synthesis of polysubstituted thiophenes from α-oxo ketene dithioacetals

Doi:10.1016/j.tetlet.2015.09.089
(2015)

Article Doi