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Conditions | Yield |
---|---|
With polymethylhydrosiloxane; bis(1,5-cyclooctadiene)diiridium(I) dichloride In tetrahydrofuran at 50℃; for 5h; | 99% |
With NiO doped titania In butan-1-ol Reagent/catalyst; Irradiation; | 93% |
With hydrogen; nickel at 120 - 140℃; |
Conditions | Yield |
---|---|
With C42H44ClN4P2Ru(1+)*Cl(1-); potassium tert-butylate; ammonium formate at 100℃; for 72h; | 95% |
With 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II); ammonium chloride; potassium hydroxide at 140℃; for 39h; Sealed tube; Inert atmosphere; | 99 %Chromat. |
Conditions | Yield |
---|---|
With BER-CuSO4 In methanol for 3h; Ambient temperature; | 93% |
With Dimethylphenylsilane In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; | 88% |
With bis(tri-n-butyltin) In tetrahydrofuran at 50℃; for 1h; | 84% |
With BER-CuSO4 In methanol for 3h; Ambient temperature; other tertiary amine N-oxides and aromatic N-oxides, var. temp. and time; |
propyl cyanide
octanol
butan-1-ol
A
tributyl-amine
B
octyldibutylamine
Conditions | Yield |
---|---|
With hydrogen; copper at 240℃; under 7600 Torr; | A n/a B 92% |
Conditions | Yield |
---|---|
With 5-methyl-1,3,4-thiadiazol-2-amine; potassium hydroxide In ethanol; water at 25℃; for 1h; | 85% |
With sodium hydroxide; urea at 120℃; under 3102.97 Torr; for 40h; | 76.5% |
With ammonia |
Conditions | Yield |
---|---|
palladium at 160℃; for 5h; | A 8% B 85% |
propyl cyanide
butan-1-ol
nonyl alcohol
A
tributyl-amine
B
1-Dibutylamino-nonan
Conditions | Yield |
---|---|
With hydrogen; copper at 240℃; under 7600 Torr; | A n/a B 85% |
Conditions | Yield |
---|---|
With hydrogen at 200℃; | A 13% B 2% C 85% |
Conditions | Yield |
---|---|
With hydrogen; copper at 240℃; under 7600 Torr; | A n/a B 84% |
Conditions | Yield |
---|---|
With chlorohydridocarbonylbis(tricyclohexylphosphine)ruthenium(II) In toluene at 120℃; for 24h; Catalytic behavior; Reagent/catalyst; Schlenk technique; Inert atmosphere; | 82% |
With aluminium trichloride | |
With palladium/alumina at 199.84℃; under 760.051 Torr; Kinetics; |
:
The Tributylamine is an organic compound with the formula C12H27N. The IUPAC name of this chemical is N,N-dibutylbutan-1-amine. With the CAS registry number 102-82-9, it is also named as 1-butanamine, N,N-dibutyl-. The product's categories are Amines; C11 to C38; Nitrogen Compounds; Analytical Reagents for General Use; Puriss p.a. ACS; T-Z, Puriss p.a. ACS. Besides, it is pale yellow liquid with an amine odour, which should be stored in a cool and well-ventilated place. It is used as oil additives, solvents, pharmaceutical intermediates, pesticides, emulsifier, plasticizer, mineral flotation agent and surface active agent.
Physical properties about Tributylamine are:
(1)ACD/LogP: 4.85; (2)ACD/LogD (pH 5.5): 1.76; (3)ACD/LogD (pH 7.4): 2.37; (4)ACD/BCF (pH 5.5): 2.34; (5)ACD/BCF (pH 7.4): 9.55; (6)ACD/KOC (pH 5.5): 8.51; (7)ACD/KOC (pH 7.4): 34.7; (8)#H bond acceptors: 1; (9)#Freely Rotating Bonds: 9; (10)Polar Surface Area: 3.24 Å2; (11)Index of Refraction: 1.437; (12)Molar Refractivity: 61.36 cm3; (13)Molar Volume: 233.8 cm3; (14)Polarizability: 24.32×10-24cm3; (15)Surface Tension: 27.4 dyne/cm; (16)Density: 0.792 g/cm3; (17)Flash Point: 63.3 °C; (18)Enthalpy of Vaporization: 45.16 kJ/mol; (19)Boiling Point: 215.3 °C at 760 mmHg; (20)Vapour Pressure: 0.149 mmHg at 25°C.
Preparation of Tributylamine:
This chemical can be prepared by butyl-methyl-amine. This reaction will need catalyst palladium black. The reaction time is 5 hours with reaction temperature of 160 °C. The yield is about 85%.
Uses of Tributylamine:
It can be used to produce methyl methyltributylammonium sulfate. The reaction time is 3 hours with reaction temperature of 80 °C. The yield is about 84.6%.
When you are using Tributylamine, please be cautious about it as the following:
It is harmful if swallowed and toxic by inhalation, in contact with skin and if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating skin and toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. When you are using it, wear suitable gloves and eye/face protection and avoid release to the environment. Refer to special instructions/safety data sheet. After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer). In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).
You can still convert the following datas into molecular structure:
(1)SMILES: N(CCCC)(CCCC)CCCC
(2)InChI: InChI=1/C12H27N/c1-4-7-10-13(11-8-5-2)12-9-6-3/h4-12H2,1-3H3
(3)InChIKey: IMFACGCPASFAPR-UHFFFAOYAY
(4)Std. InChI: InChI=1S/C12H27N/c1-4-7-10-13(11-8-5-2)12-9-6-3/h4-12H2,1-3H3
(5)Std. InChIKey: IMFACGCPASFAPR-UHFFFAOYSA-N
The toxicity data of Tributylamine is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | oral | 350mg/kg (350mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(12), Pg. 36, 1977. | |
mammal (species unspecified) | LD50 | intraperitoneal | 107mg/kg (107mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(11), Pg. 50, 1984. |
mammal (species unspecified) | LD50 | oral | 888mg/kg (888mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(11), Pg. 50, 1984. |
mouse | LD50 | oral | 114mg/kg (114mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(12), Pg. 36, 1977. | |
rabbit | LD50 | oral | 615mg/kg (615mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(12), Pg. 36, 1977. | |
rabbit | LD50 | skin | 250uL/kg (0.25mL/kg) | Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974. | |
rat | LCLo | inhalation | 75ppm/4H (75ppm) | Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974. | |
rat | LD50 | oral | 114mg/kg (114mg/kg) | Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. Vol. 115, Pg. 57, 1977. | |
rat | LDLo | subcutaneous | 380mg/kg (380mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Pharmacology and Experimental Therapeutics. Vol. 20, Pg. 435, 1923. |