2134-29-4Relevant academic research and scientific papers
Substrate inhibition in ruthenium(III) catalyzed oxidation of propane-1,3-diol by periodate in acidic medium: A kinetic study
Koteswara Rao,Nadh, R. Venkata,Ratnam, K. Venkata
, p. 1569 - 1575 (2020/07/30)
Ruthenium(III) catalyzed oxidation of propane-1,3-diol by potassium periodate was studied in aqueous perchloric acid medium. Orders of reaction with respect to concentrations of oxidant, substrate, acid and catalyst were determined. First order in oxidant and catalyst concentrations, and inverse fractional order in acid medium were observed. In addition, substrate inhibition (i.e. a decrease in reaction rate with an increase in substrate concentration) was observed. Effect of addition of salt and solvent was studied. Based on the studies of temperature variation, Arrhenius parameters were calculated. Plausible mechanism was also proposed based on observed kinetics.
Method for preparing 3-hydroxypropionaldehyde by hydrating acrolein
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Paragraph 0050-0059, (2020/12/31)
The invention relates to a method for preparing 3-hydroxy propionaldehyde by hydrating acrolein. The acrolein is homogeneously catalyzed under the action of a N-heterocyclic carboxylic acid ionic liquid to prepare 3-hydroxy propionaldehyde, wherein the hydration reaction liquid is subjected to aqueous two-phase extraction to recover the ionic liquid catalyst for cyclic utilization. According to the invention, the method is simple to operate and stable in process, the catalyst has very high reaction activity and very good selectivity, and the problems of separation of a homogeneous catalyst andinstability and easy deactivation of a solid catalyst in the hydration process are effectively solved.
Synthesis method of 3-hydroxypropionaldehyde
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Paragraph 0075; 0076; 0077, (2020/05/14)
The invention relates to a synthesis method of 3-hydroxypropionaldehyde, which mainly solves the problem of difficulty in separation of a catalyst of a homogeneous system in the prior art. The synthesis method of 3-hydroxypropionaldehyde comprises the following steps: i, adding a cobalt catalyst and a cocatalyst into a solvent, and heating for pretreatment in a synthesis gas atmosphere; and ii, after the catalyst pretreatment is finished, cooling, releasing the pressure, adding ethylene oxide and synthesis gas, and reacting to obtain the 3-hydroxypropionaldehyde, so that the technical problemis better solved, and the method can be applied to industrial production of the 3-hydroxypropionaldehyde.
1. 3 - Propanediol (by machine translation)
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Paragraph 0044, (2018/09/08)
The present invention provides a 1, 3 - propanediol, comprising the following steps: providing the mass concentration is 8% -13% of 3 - hydroxypropanal aqueous solution of; the hydrogen and 3 - hydroxypropionaldehyde mixed solution, sequentially for a period of hydrogenation reaction and secondary hydrogenation reaction, to obtain the secondary hydrogenation reaction product; part of the two-stage hydrogenation reaction product circulation to a hydrogenation reaction. The 1, 3 - propanediol, through a portion of a two-stage hydrogenation reaction product circulation to a hydrogenation reaction, the absorption of the reaction heat, reducing the temperature of the hydrogenation reaction of the 1st hot spots, can effectively reduce the acetal impurity content in the product, improve the selectivity of the hydrogenation reaction. (by machine translation)
Micellar effect on hetero-aromatic nitrogen base promoted chromic acid oxidation of 1.3-propanediol in aqueous media at room temperature
Malik, Susanta,Saha, Debabrata,Mondal, Monohar Hossain,Sar, Pintu,Ghosh, Aniruddha,Mahali, Kalachand,Saha, Bidyut
, p. 207 - 216 (2016/12/06)
Surfactants are classified on the basis of the nature of the hydrophilic groups. Surfactant micelle represents a tiny template or nanoreactor which is generally used for preparing nano-structured materials of desired sizes and shapes with required functionalities. In this present investigation chromic acid oxidation of 1.3-propanediol (1.3-PDO) to 3-hydroxy propionaldehyde (3-HPA) was carried out by using four representative promoters: picolinic acid (PA), 2.3-pyridine dicarboxylic acid (2.3 diPA), 2.2′-bipyridine (bipy) and 1.10-phenanthroline (phen) in presence and absence of surfactants sodium dodecylsulphate (SDS), N-cetylpyridinium chloride (CPC) and Triton-X-100 (TX-100). Reactions were performed under pseudo-first-order condition: [1.3-PDO]T ? [Cr(VI)]T in aqueous media at 30 °C temperature. Different combinations were performed to select the suitable combination of promoter and micellar catalyst for this oxidation. Based on the kinetic results, combination of TX-100 and phen was found to be the most suitable one for this oxidation. The mechanisms of both unpromoted and promoted reaction paths were proposed. The product was confirmed by 2.4-DNP test followed by FTIR spectroscopy of the hydrazone derivative.
Preparation method of 3-hydroxy-propionaldehyde
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Paragraph 0046; 0049, (2017/08/29)
The invention relates to a preparation method of 3-hydroxy-propionaldehyde. The preparation method mainly solves the problem that a homogeneous system catalyst is difficult to recycle in the prior art. The preparation method of the 3-hydroxy-propionaldehyde comprises the following steps: a) performing a complexing reaction in a solvent on ligand and cobalt carbonyl so as to obtain a catalyst solution; and b) adding oxacyclopropane and synthesis gas, and reacting to obtain the 3-hydroxy-propionaldehyde, wherein the ligand is of a following structure, X is selected form one of an oxygen atom and a sulfur atom, and R is selected from one of a cyclo group, an aryl group or a substituted aryl group. Through the technical scheme, the technical problem is preferably solved, and the preparation method can be used in industrial production of the 3-hydroxy-propionaldehyde.
Catalytic glycerol hydrogenolysis to 1,3-propanediol in a gas-solid fluidized bed
Edake, Mahesh,Dalil, Marjan,Darabi Mahboub, Mohammad Jaber,Dubois, Jean-Luc,Patience, Gregory S.
, p. 3853 - 3860 (2017/02/05)
Glycerol is a potential feedstock to produce 1,3-propanediol (1,3-PDO), which is a valuable commercial polyester monomer. Here, we report the gas-phase glycerol hydrogenolysis to 1,3-propanediol over Pt/WO3/Al2O3 in a fluidized bed operating above 240 °C and at ambient pressure. Fluidized beds are ideal contactors for this reaction because the heat transfer rates are sufficiently high to vaporize glycerol thereby minimizing its combustion and thermal degradation. The yield of 1,3-PDO approached 14% after 2 h at 260 °C. The major co-products were 1,2-PDO (18%), 1-propanol (28%) and 2-propanol (15%). In the first step, glycerol may dehydrate to acrolein, followed by rehydration to 3-hydroxypropanal and then hydrogenation to 1,3-PDO. The concentrations of the by-products including acrolein, ethylene glycol, propane, and acetone increased with increasing temperature.
Syntheses and biological evaluation of 1,2,3-triazole and 1,3,4-oxadiazole derivatives of imatinib
Li, Yong-Tao,Wang, Jing-Han,Pan, Cheng-Wen,Meng, Fan-Fei,Chu, Xiao-Qian,Ding, Ya-Hui,Qu, Wen-Zheng,Li, Hui-Ying,Yang, Cheng,Zhang, Quan,Bai, Cui-Gai,Chen, Yue
, p. 1419 - 1427 (2016/02/19)
Three novel series of 1,2,3-triazole and 1,3,4-oxadiazole derivatives of imatinib were prepared and evaluated in vitro for their cytostatic effects against a human chronic myeloid leukemia (K562), acute myeloid leukemia (HL60), and human leukemia stem-like cell line (KG1a). The structure-activity relationship was analyzed by determining the inhibitory rate of each imatinib analog. Benzene and piperazine rings were necessary groups in these compounds for maintaining inhibitory activities against the K562 and HL60 cell lines. Introducing a trifluoromethyl group significantly enhanced the potency of the compounds against these two cell lines. Surprisingly, some compounds showed significant inhibitory activities against KG1a cells without inhibiting common leukemia cell lines (K562 and HL60). These findings suggest that these compounds are able to inhibit leukemia stem-like cells.
Unsymmetrical Bis Azainositol Hafnium Complexes for X-Ray Imaging
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Paragraph 0128, (2014/11/11)
The present invention describes a new class of trinuclear hafnium complexes comprising two hexadentate azainositol carboxylic acid ligands, methods for their preparation and their use as X-ray contrast agents.
Influence of acid-base sites on ZnO-ZnCr2O4 catalyst during dehydrocyclization of aqueous glycerol and ethylenediamine for the synthesis of 2-methylpyrazine: Kinetic and mechanism studies
Venugopal, Akula,Sarkari, Reema,Anjaneyulu, Chatla,Krishna, Vankudoth,Kumar, Mandari Kotesh,Narender, Nama,Padmasri, Aytam Hari
, p. 398 - 409 (2013/11/19)
The physicochemical characteristics of ZnO-ZnCr2O4 (Zn-Cr-O) mixed oxides were determined by adsorption and spectroscopic methods. The catalytic activities of Zn-Cr-O was investigated for dehydrocyclization of ethylenediamine and aqu
