2595-97-3Relevant academic research and scientific papers
New 3,4-seco-diterpene and coumarin derivative from the leaves of Trigonostemon flavidus Gagnep
Ban, Ninh Khac,Linh, Tran My,Mai, Nguyen Chi,Tai, Bui Huu,Nhiem, Nguyen Xuan,Hoang, Nguyen Huy,Kiem, Phan Van
, p. 3247 - 3254 (2022)
Two new compounds named trigoflavidus A (1) and trigoflavidus B (2), and eight known compounds, trigoflavidone (3), heterophypene (4), howpene C (5), 3,4-seco-sonderianol (6), trigonochinene C (7), fraxidin (8), isofraxidin (9), and isofraxetin (10) were isolated from the leaves of Trigonostemon flavidus Gagnep. by various chromatographic methods. Their chemical structures were elucidated via UV, IR, HR-ESI-MS and NMR spectroscopic methods and divided into two groups including six 3,4-seco-diterpenes (1, 3-7) and four coumarins (2, 8-10). Absolute configurations at stereocenters of compound 1 were confirmed by comparison of its CD spectra with those of the TD-DFT calculations. At a concentration of 30 μM, compounds 1–10 exhibited weak cytotoxic activity toward LU1, HepG2, MCF7, and SKMel2 human cell lines (cell viability all over 50%).
Seven new glycosides from the leaves of Datura metel L.
Tan, Jin-Yan,Liu, Yan,Cheng, Yan-Gang,Sun, Yan-Ping,Li, Xiao-Mao,Guan, Wei,Pan, Juan,Yang, Bing-You,Kuang, Hai-Xue
, p. 295 - 304 (2021)
Seven new glycosides (1–7) and seventeen known analogues (8–24) were isolated from the leaves of Datura metel L. The structures of these compounds were all elucidated by detailed spectroscopic analyses and comparison with literature values. All isolates were evaluated for cytotoxicity against Hela, MGC-803, Ishikawa cell lines and compounds 6, 7, 14–17 and 24 exhibited different degrees of antiproliferative effects.
Cucurbitane-type triterpene glycosides from the fruits of Momordica charantia
Kim, Young Ho,Nhiem, Nguyen Xuan,Kiem, Phan Van,Minh, Chau Van,Ban, Ninh Khac,Cuong, Nguyen Xuan,Ha, Le Minh,Tai, Bui Huu,Quang, Tran Hong,Tung, Nguyen Huu
, p. 392 - 396 (2010)
The chemical study of Momordica charantia fruits led to the isolation of three new cucurbitane triterpene glycosides, momordicosides U, V, and W (1-3). The structures of these compounds were determined to be (19R,23R)-5β, 19-epoxy-19-methoxycucurbita-6,24-diene-3β, 23-diol 3-O-β-D- allopyranoside (1), (23R)-5β, 19-epoxycucurbita-6,24-diene-3β, 23-diol 3-O-β-D-allopyranoside (2), and (19R)-5β, 19-epoxy-19,25- dihydroxycucurbita-6,23(E)-diene-3β-ol 3-O-β-D-glucopyranoside (3), by chemical and spectroscopic methods.
Two new compounds from Aconitum tanguticum
Li, Yan-Rong,Xu, Lu,Li, Chun,Wang, Zhi-Min,Yang, Li-Xin
, p. 730 - 734 (2014)
A phytochemical investigation on the whole plant of Aconitum tanguticum (Ranunculaceae) resulted in the isolation and characterization of two new phenylpropanoid glycosides (1 and 2). Their structures were elucidated as 4-hydroxyphenethoxy-8-O-β-d-[6-O-(4-O-β-d-glucopyranosyl)-sinapoyl] -glucopyranoside (1) and 3,4-dimethoxy-trans-cinnamic acid-9-O-β-d- allopyranoside (2) on the basis of spectroscopic data (1D NMR, 2D NMR, and MS) and comparison with the literature data. 2014
Acute and sub-chronic toxicity of D-allose in rats
Iga, Yusuke,Nakamichi, Kazunori,Shirai, Yoko,Matsuo, Tatsuhiro
, p. 1476 - 1478 (2010)
We examined the acute and sub-chronic toxicity of D-allose in rats. In the acute toxicity test, the calculated LD50 value was 20.5 g/kg. In the sub-chronic toxicity test, no difference was found among the four groups in most of the serum chemical and hematological test results. These results suggest that D-allose is not toxic to rats.
Cucurbitane-type triterpenoids from the fruits of Momordica charantia and their cancer chemopreventive effects
Akihisa, Toshihiro,Higo, Naoki,Tokuda, Harukuni,Ukiya, Motohiko,Akazawa, Hiroyuki,Tochigi, Yuichi,Kimura, Yumiko,Suzuki, Takashi,Nishino, Hoyoku
, p. 1233 - 1239 (2007)
Thirteen cucurbitane-type triterpene glycosides, including eight new compounds named charantosides I (6), II (7), III (10), IV (11), V (12), VI (13), VII (16), and VIII (17), and five known compounds, 8, 9, 14, 15, and 18, were isolated from a methanol extract of the fruits of Japanese Momordica charantia. The structures of the new compounds were determined on the basis of spectroscopic methods. On evaluation of these triterpene glycosides and five other cucurbitane-type triterpenes, 1-5, also isolated from the extract of M. charantia fruits, for their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, these compounds showed inhibitory effects on EBV-EA induction with IC50 values of 200-409 mol ratio/32 pmol TPA. In addition, upon evaluation of compounds 1-5 for inhibitory effects against activation of (±)-(E)-methyl-2[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitrogen oxide (NO) donor, compounds 1-3 showed moderate inhibitory effects. Compounds 1 and 2 exhibited marked inhibitory effects in both 7,12-dimethylbenz[a]anthracene (DMBA)- and peroxynitrite (ONOO-; PN)-induced mouse skin carcinogenesis tests.
Chemical constituents from cimicifuga dahurica and their anti-proliferative effects on MCF-7 breast cancer cells
Thanh Huyen, Chu Thi,Thuy Luyen, Bui Thi,Khan, Ghulam Jilany,Oanh, Ha Van,Hung, Ta Manh,Li, Hui-Jun,Li, Ping
, (2018)
This study was designed to search for novel anti-cancer compounds from natural plants. The 70% ethanolic extract from the rizhomes of Cimicifuga dahurica (Turcz.) Maxim. (Ranunculaceae) was found to possess significant in vitro anti-proliferative effects
Phenolic glycosides from the Chinese liverwort reboulia hemisphaerica
Wang, Li-Ning,Guo, Dong-Xiao,Wang, Shu-Qi,Wu, Chang-Sheng,Rehman, Mujeeb Ur,Lou, Hong-Xiang
, p. 1146 - 1152 (2011)
Four new phenolic glycosides, named rebouosides A-D (1-4, resp.), along with three known ones 2-(3,4-dihydroxyphenyl)ethyl 2-O-α-L- rhamnopyranosyl-β-D-allopyranoside (5), 2-(3,4-dihydroxyphenyl)ethyl β-D-allopyranoside (6), 2-(3,4-dihydroxyphenyl)ethyl β-D- glucopyranoside (7), and a nucleoside, inosine (8), were isolated from Chinese liverwort Reboulia hemisphaerica. Their structures were elucidated by acidic hydrolysis and extensive spectroscopic methods, including 2D-NMR techniques.
5β,19-Epoxycucurbitane triterpenoids from momordica charantia and their anti-inflammatory and cytotoxic activity
Liaw, Chia-Ching,Huang, Hui-Chi,Hsiao, Ping-Chun,Zhang, Li-Jie,Lin, Zhi-Hu,Hwang, Syh-Yuan,Hsu, Feng-Lin,Kuo, Yao-Haur
, p. 62 - 70 (2015)
Five new 5β,19-epoxycucurbitane triterpenoids, taikugausins A-E (1 -5), together with 5β,19-epoxy-25-methoxycucurbita-6,23-diene-3β,19-diol (6), have been isolated and characterized from the 70% EtOH extract of the fresh fruits of Momordica charantia. The
HPLC-ESIMSn profiling, isolation, structural elucidation, and evaluation of the antioxidant potential of phenolics from Paepalanthus geniculatus
Pereira Do Amaral, Fabiano,Napolitano, Assunta,Masullo, Milena,Campaner Dos Santos, Lourdes,Festa, Michela,Vilegas, Wagner,Pizza, Cosimo,Piacente, Sonia
, p. 547 - 556 (2012)
The methanol extract of the flowers of Paepalanthus geniculatus Kunth. showed radical-scavenging activity in the TEAC assay. An analytical approach based on HPLC-ESIMSn was applied to obtain the metabolite profile of this extract and led to the rapid identification of 19 polyphenolic compounds comprising flavonoids and naphthopyranones. The new naphthopyranone (10, 16), quercetagetin (1, 5, 7, 13), and galetine derivatives (9, 11, 17, 19), and a flavonol glucoside cyclodimer in the truxillate form (12), were identified. Compounds 2, 6, and 7 showed the highest antioxidant capacity and ability to affect the levels of intracellular ROS in human prostate cancer cells (PC3).
