373-80-8

Basic information

• Product Name: TRIFLUOROMETHYLSULFUR PENTAFLUORIDE
• Synonyms: TRIFLUOROMETHYLSULFUR PENTAFLUORIDE;TRIFLUOROMETHYLSULPHUR PENTAFLUORIDE;CF3SF5;Pentafluoro(trifluoromethyl)sulfur;pentafluoro(trifluoro-methyl)sulfur;Sulfur, pentafluoro(trifluoromethyl)-, (OC-6-21)-;Trifluoromethylsulphur pentafluoride 99%;Trifluoromethylsulphurpentafluoride99%
• CAS NO: 373-80-8
• Molecular Formula: CF₈S
• Molecular Weight: 196.06
• Mol File: 373-80-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: -87°C
• Boiling Point: -21 °C
• Flash Point: °C
• Appearance: /liquid
• Density: g/cm³
• CAS DataBase Reference: TRIFLUOROMETHYLSULFUR PENTAFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIFLUOROMETHYLSULFUR PENTAFLUORIDE(373-80-8)
• EPA Substance Registry System: TRIFLUOROMETHYLSULFUR PENTAFLUORIDE(373-80-8)

Safety Data

• Statements: 23-34
• Safety Statements: 3/7-9-26-36/37/39-45
• RIDADR: 3308
• Hazardous Substances Data: 373-80-8(Hazardous Substances Data)

Usage

General Description

TRIFLUOROMETHYLSULFUR PENTAFLUORIDE is a chemical compound with the formula CF3SF5. It is a colorless, odorless gas that is highly reactive and can decompose violently in the presence of moisture or heat. TRIFLUOROMETHYLSULFUR PENTAFLUORIDE is primarily used as a strong fluorinating agent in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is also used in the manufacturing of high-performance plastics and polymers. Due to its reactivity and potential hazards, TRIFLUOROMETHYLSULFUR PENTAFLUORIDE must be handled with extreme caution and under strict safety protocols.

InChI:InChI=1/CF8S/c2-1(3,4)10(5,6,7,8)9

Synthetic route

Bis(trifluoromethyl)disulfid (372-64-5) + chlorine monofluoride (7790-89-8) → trifluoromethyl sulfur pentafluoride (373-80-8) + trans-chlorotetrafluoro(trifluoromethyl)sulfur(VI) (25030-42-6, 42179-04-4)

Conditions	Yield
molar ratio of CF3SSCF3 and ClF = 1:8.5 to 1:9, 10 h, 25°c;	A <1 B 76.8%
molar ratio of CF3SSCF3 and ClF = 1:8.5 to 1:9, 10 h, 25°c;	A <1 B 76.8%

carbon disulfide (75-15-0) + cobalt(III) fluoride (10026-18-3) → trifluoromethyl sulfur pentafluoride (373-80-8)

Conditions	Yield
250°C;	40%
250°C;	40%

cobalt(III) fluoride (10026-18-3) + methylthiol (74-93-1) → trifluoromethyl sulfur pentafluoride (373-80-8)

Conditions	Yield
250-275°C , diluted with N2;	20%
250-275°C , diluted with N2;	20%
190-210°C , diluted with N2;	15%

1-butanethiol (109-79-5) + hydrogen fluoride (7664-39-3) → pentafluoro(1,1,2,2,2-pentafluoroethyl)-λ6-sulfane (354-67-6) + n-C4F9SF5 (375-52-0) + trifluoromethyl sulfur pentafluoride (373-80-8)

Conditions	Yield
In further solvent(s) Electrochem. Process; electrofluorination in anhyd. HF for 6 h 40 min 15°C, helium flow rate 60 mL/min, U=5.8-8.0 V, i=2.9 A/dm2;	A n/a B 12.3% C n/a
In further solvent(s) Electrochem. Process; electrofluorination in anhyd. HF for 6 h 40 min 15°C, helium flow rate 60 mL/min, U=5.8-8.0 V, i=2.9 A/dm2;	A n/a B 12.3% C n/a

carbon disulfide (75-15-0) + fluorine (7782-41-4) → trifluoromethyl sulfur pentafluoride (373-80-8)

Conditions	Yield
48°C , T-reactor, CS2:F2:N2=1:5:75;	9%
48°C , T-reactor, CS2:F2:N2=1:5:75;	9%
40°C , diluted with N2;
40°C , diluted with N2;

carbon disulfide (75-15-0) → trifluoromethyl sulfur pentafluoride (373-80-8)

Conditions	Yield
With hydrogen fluoride elektrochemische Fluorierung an einer Nickel-Anode;
With cobalt (III) fluoride at 250℃;
electrofluorination;

carbon disulfide (75-15-0) → trifluoromethyl sulfur pentafluoride (373-80-8) + trifluoro(trifluoromethyl)sulfur(IV) (374-10-7)

Conditions	Yield
With silver(II) fluoride

bis(trifluoromethyl)trithiocarbonate (461-08-5) → Bis(trifluoromethyl)disulfid (372-64-5) + trifluoromethyl sulfur pentafluoride (373-80-8) + trifluoro(trifluoromethyl)sulfur(IV) (374-10-7) + trifluoromethanesulfinyl fluoride (812-12-4)

Conditions	Yield
With silver(II) fluoride; sodium fluoride In 1,1,2-Trichloro-1,2,2-trifluoroethane
With silver(II) fluoride; sodium fluoride

hydrogen fluoride (7664-39-3) + [1,3,5]trithiane (291-21-4) + nickel electrodes → trifluoromethyl sulfur pentafluoride (373-80-8) + (difluoromethanediyl)bis(pentafluorosulfur(VI)) (1512-21-6) + pentafluorothiodifluoromethyl-trifluoromethylsulfurtetrafluoride (1543-46-0) + octadecafluoro-1λ6,3λ6,5λ6-<1,3,5>trithiane

Conditions	Yield
Electrolysis;

carbon disulfide (75-15-0) + cobalt (III)-fluoride → trifluoromethyl sulfur pentafluoride (373-80-8)

Conditions	Yield
at 200 - 250℃;

carbon disulfide (75-15-0) + hydrogen fluoride (7664-39-3) → trifluoromethyl sulfur pentafluoride (373-80-8) + (difluoromethanediyl)bis(pentafluorosulfur(VI)) (1512-21-6) + difluoro-bis-4-sulfanyl>-methane

Conditions	Yield
Anodische Fluorierung.Electrolysis;

methylthiol (74-93-1) + cobalt (III)-fluoride → trifluoromethyl sulfur pentafluoride (373-80-8)

Conditions	Yield
at 250℃;

methylthiol (74-93-1) + fluorine + nitrogen + silver fluoride/ copper → trifluoromethyl sulfur pentafluoride (373-80-8)

Conditions	Yield
at 200℃;

Bis(trifluoromethyl)disulfid (372-64-5) + cobalt (III)-fluoride + nitrogen → carbon tetrafluoride (75-73-0) + trifluoromethyl sulfur pentafluoride (373-80-8)

Conditions	Yield
at 150℃;

dimethylsulfide (75-18-3) → trifluoromethyl sulfur pentafluoride (373-80-8) + tetrafluoro-bis-trifluoromethyl-λ6-sulfane

Conditions	Yield
With hydrogen fluoride elektrochemische Fluorierung an einer Nickel-Anode;

dimethylsulfide (75-18-3) + hydrogen fluoride (7664-39-3) → trifluoromethyl sulfur pentafluoride (373-80-8) + tetrafluoro-bis-trifluoromethyl-sulfur

Conditions	Yield
elektrochemische Fluorierung;

(methylthio)acetyl chloride (35928-65-5) + hydrogen fluoride (7664-39-3) → trifluoromethyl sulfur pentafluoride (373-80-8) + tetrafluoro-bis-trifluoromethyl-λ6-sulfane + tetrafluoro-pentafluoroethyl-trifluoromethyl-λ6-sulfane + -tetrafluoro-trifluoromethyl-λ6-sulfane

Conditions	Yield
elektrochemische Fluorierung an einer Nickel-Anode; Produkt5:Octafluor-1,2-bis-trifluormethyl-λ6,λ6-disulfan(?);

chlorodifluoromethansulfenylchloride (993-38-4) + silver(II) fluoride → trifluoromethyl sulfur pentafluoride (373-80-8) + trifluoro(trifluoromethyl)sulfur(IV) (374-10-7) + Chlordifluormethyl-trifluor-sulfuran (63177-64-0)

Conditions	Yield
at 60 to 70°C;
60-70°C, 10 min;
60-70°C, 10 min;
at 60 to 70°C;

silver(II) fluoride + bis(trifluoromethyl)trithiocarbonate (461-08-5) → trifluoromethyl sulfur pentafluoride (373-80-8)

dimethylsulfide (75-18-3) → trifluoromethyl sulfur pentafluoride (373-80-8)

Conditions	Yield
electrofluorination;
electrofluorination;

Dimethyldisulphide (624-92-0) → trifluoromethyl sulfur pentafluoride (373-80-8)

Conditions	Yield
electrofluorination;
electrofluorination;

cobalt(III) fluoride (10026-18-3) + Bis(trifluoromethyl)disulfid (372-64-5) → trifluoromethyl sulfur pentafluoride (373-80-8)

Conditions	Yield
high yield;
150°C , 8 h;

[1,3,5]trithiane (291-21-4) → trifluoromethyl sulfur pentafluoride (373-80-8)

Conditions	Yield
electrofluorination;
electrofluorination;

(methylthio)acetyl chloride (35928-65-5) → trifluoromethyl sulfur pentafluoride (373-80-8)

Conditions	Yield
electrofluorination;

carbon disulfide (75-15-0) + silver(II) fluoride → trifluoromethyl sulfur pentafluoride (373-80-8)

silver(II) fluoride + bis-(trifluoromethyl)sulfide (371-78-8) → carbon tetrafluoride (75-73-0) + trifluoromethyl sulfur pentafluoride (373-80-8)

Conditions	Yield
slowly reaction at 150-225°C;

silver(II) fluoride + Bis(trifluoromethyl)disulfid (372-64-5) → trifluoromethyl sulfur pentafluoride (373-80-8)

Bis(trifluoromethyl)disulfid (372-64-5) → trifluoromethyl sulfur pentafluoride (373-80-8)

Conditions	Yield
With fluorine -120°C, in a continuous-flow reactor, 72 h;
With fluorine -120°C, in a continuous-flow reactor, 72 h;

chlorodifluoromethansulfenylchloride (993-38-4) + silver(II) fluoride → trifluoro(chlorodifluoromethyl)sulfur(IV) + trifluoromethyl sulfur pentafluoride (373-80-8) + trifluoro(trifluoromethyl)sulfur(IV) (374-10-7)

trifluoromethyl sulfur pentafluoride (373-80-8) + Perfluoro-2-azapropen (371-71-1) → perfluorotrimethylamine (432-03-1)

Conditions	Yield
With sodium fluoride at 540℃;

trifluoromethyl sulfur pentafluoride (373-80-8) + hexafluoro-2-butyne (692-50-2) → heptafluoro-2,3,4-tris-trifluoromethyl-hexa-2,4-diene (3825-03-4) + 1,1,1,6,6,6-hexafluoro-2,3,4,5-tetrakis-trifluoromethyl-hexa-2,4-diene (2342-10-1)

Conditions	Yield
at 525℃;

trifluoromethyl sulfur pentafluoride (373-80-8) + hexafluoro-2-butyne (692-50-2) → 1,1,1,6,6,6-hexafluoro-2,3,4,5-tetrakis-trifluoromethyl-hexa-2,4-diene (2342-10-1)

Conditions	Yield
at 525℃;

trifluoromethyl sulfur pentafluoride (373-80-8) + hexafluoro-2-butyne (692-50-2) → 1,1,1,6,6,6-hexafluoro-2,3,4,5-tetrakis-trifluoromethyl-hexa-2,4-diene (2342-10-1) + heptafluoro-2,3,4-tris-trifluoromethyl-hexa-2,4ξ-diene

Conditions	Yield
at 525℃;

perfluoropropylene (116-15-4) + trifluoromethyl sulfur pentafluoride (373-80-8) → perfluorobutane (355-25-9) + branched and unbranched perfluoroalkanes with five and more carbon-atomene

Conditions	Yield
at 512 - 518℃;

trifluoromethyl sulfur pentafluoride (373-80-8) + hexalfluoro-but-2-yne → 1,1,1,6,6,6-hexafluoro-2,3,4,5-tetrakis-trifluoromethyl-hexa-2,4-diene (2342-10-1) + heptafluoro-2,3,4-tris-trifluoromethyl-hexa-2,4ξ-diene

Conditions	Yield
at 525℃;

trifluoromethyl sulfur pentafluoride (373-80-8) → Hexafluoroethane (76-16-4) + tetrafluoro-λ4-sulfane

Conditions	Yield
at 500℃; under 760 Torr; Pyrolysis;

trifluoromethyl sulfur pentafluoride (373-80-8) → trifluoromethylium (18851-76-8)

Conditions	Yield
With N2O(1+) at 26.85℃; Kinetics; Further Variations:; Reagents;

trifluoromethyl sulfur pentafluoride (373-80-8) → carbon tetrafluoride (75-73-0)

Conditions	Yield
With Ne+ at 26.85℃; under 0.5 Torr; Kinetics; Thermodynamic data; Further Variations:; Reagents;

trifluoromethyl sulfur pentafluoride (373-80-8) → carbon tetrafluoride (75-73-0) + sulfur tetrafluoride (7783-60-0)

Conditions	Yield
Electrochem. Process; at 4-200 Torr;
Electrochem. Process; at 4-200 Torr;

trifluoromethyl sulfur pentafluoride (373-80-8) → Hexafluoroethane (76-16-4) + sulfur tetrafluoride (7783-60-0)

Conditions	Yield
at 500°C;

Upstream product

• 75-15-0 carbon disulfide 
• 7664-39-3 hydrogen fluoride 
• 291-21-4 [1,3,5]trithiane 
• 74-93-1 methylthiol 
• 372-64-5 Bis(trifluoromethyl)disulfid 
• 75-18-3 dimethylsulfide 
• 35928-65-5 (methylthio)acetyl chloride 
• 461-08-5 bis(trifluoromethyl)trithiocarbonate 
• 624-92-0 Dimethyldisulphide 
• 10026-18-3 cobalt(III) fluoride 
• 371-78-8 bis-(trifluoromethyl)sulfide 
• 993-38-4 chlorodifluoromethansulfenylchloride 
• 2314-97-8 iodotrifluoromethane 
• 1186-51-2 (trifluoroethenyl)pentafluorosulfur(VI) 

Downstream Products

• 355-25-9 perfluorobutane 
• 76-16-4 Hexafluoroethane 
• 75-73-0 carbon tetrafluoride 
• 7783-60-0 sulfur tetrafluoride 
• 7440-44-0 pyrographite 
• 335-57-9 perfluoroheptane 
• 355-42-0 tetradecafluorohexane 
• 678-26-2 perfluoropentane 
• 432-03-1 perfluorotrimethylamine 
• 14700-00-6 octafluorophosphazene 
• 15599-91-4 hexafluorophosphazene 
• 7783-55-3 trifluorophosphane 

Relevant articles and documents

-

-

-

-