TRIFLUOROMETHYLSULFUR PENTAFLUORIDE, with the chemical formula CF3SF5, is a colorless, odorless gas that exhibits high reactivity. It can decompose violently when exposed to moisture or heat, necessitating careful handling and strict safety measures.

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Basic information
1. Product Name: TRIFLUOROMETHYLSULFUR PENTAFLUORIDE
2. Synonyms: TRIFLUOROMETHYLSULFUR PENTAFLUORIDE;TRIFLUOROMETHYLSULPHUR PENTAFLUORIDE;CF3SF5;Pentafluoro(trifluoromethyl)sulfur;pentafluoro(trifluoro-methyl)sulfur;Sulfur, pentafluoro(trifluoromethyl)-, (OC-6-21)-;Trifluoromethylsulphur pentafluoride 99%;Trifluoromethylsulphurpentafluoride99%
3. CAS NO:373-80-8
4. Molecular Formula: CF₈S
5. Molecular Weight: 196.06
6. EINECS: N/A
7. Product Categories: N/A
8. Mol File: 373-80-8.mol
Chemical Properties
1. Melting Point: -87°C
2. Boiling Point: -21 °C
3. Flash Point: °C
4. Appearance: /liquid
5. Density: g/cm³
6. Refractive Index: N/A
7. Storage Temp.: N/A
8. Solubility: N/A
9. CAS DataBase Reference: TRIFLUOROMETHYLSULFUR PENTAFLUORIDE(CAS DataBase Reference)
10. NIST Chemistry Reference: TRIFLUOROMETHYLSULFUR PENTAFLUORIDE(373-80-8)
11. EPA Substance Registry System: TRIFLUOROMETHYLSULFUR PENTAFLUORIDE(373-80-8)
Safety Data
1. Hazard Codes: N/A
2. Statements: 23-34
3. Safety Statements: 3/7-9-26-36/37/39-45
4. RIDADR: 3308
5. WGK Germany:
6. RTECS:
7. HazardClass: N/A
8. PackingGroup: N/A
9. Hazardous Substances Data: 373-80-8(Hazardous Substances Data)

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Used in Organic Synthesis:
TRIFLUOROMETHYLSULFUR PENTAFLUORIDE is used as a strong fluorinating agent for the synthesis of various organic compounds, particularly in the production of pharmaceuticals and agrochemicals. Its strong fluorinating properties enable the efficient incorporation of fluorine into target molecules, enhancing their chemical and biological properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, TRIFLUOROMETHYLSULFUR PENTAFLUORIDE is utilized as a fluorinating agent to introduce fluorine atoms into drug molecules. The presence of fluorine can improve the pharmacokinetic and pharmacodynamic properties of drugs, such as increasing their lipophilicity, metabolic stability, and bioavailability. This leads to enhanced therapeutic efficacy and reduced side effects.
Used in Agrochemical Industry:
TRIFLUOROMETHYLSULFUR PENTAFLUORIDE is also employed in the agrochemical industry for the synthesis of fluorinated pesticides and herbicides. The introduction of fluorine atoms can enhance the biological activity, selectivity, and environmental persistence of these agrochemicals, leading to improved crop protection and reduced environmental impact.
Used in High-Performance Plastics and Polymers:
In the plastics and polymers industry, TRIFLUOROMETHYLSULFUR PENTAFLUORIDE is used as a fluorinating agent to produce high-performance materials with exceptional properties. The incorporation of fluorine atoms can impart characteristics such as increased thermal stability, chemical resistance, and non-stick properties, making these materials suitable for various demanding applications, including aerospace, automotive, and electronics.
Due to the high reactivity and potential hazards associated with TRIFLUOROMETHYLSULFUR PENTAFLUORIDE, it must be handled with extreme caution and under strict safety protocols to prevent accidents and ensure the safety of personnel and the environment.

Check Digit Verification of cas no

The CAS Registry Mumber 373-80-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,7 and 3 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 373-80:
(5*3)+(4*7)+(3*3)+(2*8)+(1*0)=68
68 % 10 = 8
So 373-80-8 is a valid CAS Registry Number.

InChI:InChI=1/CF8S/c2-1(3,4)10(5,6,7,8)9

373-80-8Synthetic route

: 372-64-5
Bis(trifluoromethyl)disulfid

: 7790-89-8
chlorine monofluoride

A: 373-80-8
trifluoromethyl sulfur pentafluoride

B: 25030-42-6, 42179-04-4
trans-chlorotetrafluoro(trifluoromethyl)sulfur(VI)

Conditions	Yield
molar ratio of CF3SSCF3 and ClF = 1:8.5 to 1:9, 10 h, 25°c;	A <1 B 76.8%
molar ratio of CF3SSCF3 and ClF = 1:8.5 to 1:9, 10 h, 25°c;	A <1 B 76.8%

Conditions	Yield
250-275°C , diluted with N2;	20%
250-275°C , diluted with N2;	20%
190-210°C , diluted with N2;	15%

Conditions	Yield
In further solvent(s) Electrochem. Process; electrofluorination in anhyd. HF for 6 h 40 min 15°C, helium flow rate 60 mL/min, U=5.8-8.0 V, i=2.9 A/dm2;	A n/a B 12.3% C n/a
In further solvent(s) Electrochem. Process; electrofluorination in anhyd. HF for 6 h 40 min 15°C, helium flow rate 60 mL/min, U=5.8-8.0 V, i=2.9 A/dm2;	A n/a B 12.3% C n/a

Conditions	Yield
48°C , T-reactor, CS2:F2:N2=1:5:75;	9%
48°C , T-reactor, CS2:F2:N2=1:5:75;	9%
40°C , diluted with N2;
40°C , diluted with N2;

Conditions	Yield
With hydrogen fluoride elektrochemische Fluorierung an einer Nickel-Anode;
With cobalt (III) fluoride at 250℃;
electrofluorination;

Conditions	Yield
With silver(II) fluoride; sodium fluoride In 1,1,2-Trichloro-1,2,2-trifluoroethane
With silver(II) fluoride; sodium fluoride

Conditions	Yield
at 60 to 70°C;
60-70°C, 10 min;
60-70°C, 10 min;
at 60 to 70°C;

Conditions	Yield
With fluorine -120°C, in a continuous-flow reactor, 72 h;
With fluorine -120°C, in a continuous-flow reactor, 72 h;

Conditions	Yield
Electrochem. Process; at 4-200 Torr;
Electrochem. Process; at 4-200 Torr;

Conditions	Yield
250°C;	40%
250°C;	40%

373-80-8

Basic information

Chemical Properties

Safety Data

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373-80-8 Usage

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373-80-8Synthetic route

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