Proposed mechanisms for R-KG-dependent enzymes

June 21, 2024

• Title:       

  Proposed mechanisms for R-KG-dependent enzymes

• Image Source:

  Iron(II) complexes of sterically bulky α-ketocarboxylates. Structural models for α-ketoacid-dependent nonheme iron halogenases

• Mark:

  Figure 1

• Associated context:

  These halogenase enzymes are homologous to those that use O₂ (CAS 7782-44-7) and α-keto-glutarate (α-KG) to perform substrate oxidations, and similar mechanisms for the generation of the proposed Fe^IV=O active oxidant have been proposed (Figure 1).