Retrosynthetic analysis of amphidinolide H (1)

July 08, 2024

• Title:       

  Retrosynthetic analysis of amphidinolide H (1)

• Image Source:

  Total syntheses of amphidinolide H and G

• Mark:

  Scheme 1

• Associated context:

  For the sake of convergence, 1 was dissected into four building blocks which were to be combined by esterification, an aldol reaction, metal-catalyzed cross-coupling, and olefin metathesis (Scheme 1).