The general scheme of formation of captodative carbonyl-bearing aminoalkenes

July 22, 2024

• Title:       

  The general scheme of formation of captodative carbonyl-bearing aminoalkenes

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  Mechanistic study of multi-step nucleophilic substitution for trifluoromethylated styrenes

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  Scheme 1

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  Thus, the  formation of captodative carbonyl-bearing aminoalkenes is a multi-step (Ad-SN2-E) process and occurs via nucleophilic addition of one  equivalent of amine to the activated double bond of the initial  substrate, followed by classical substitution of the halogen atom at  the sp3-carbon center by second amine equivalent and finally a the sp3-carbon center by second amine equivalent and finally an elimination of b-amine to produce captodative enamine derivative (Scheme 1) [2a].