The reactivity of trifluoromethylated styrenes

July 22, 2024

• Title:       

  The reactivity of trifluoromethylated styrenes

• Image Source:

  Mechanistic study of multi-step nucleophilic substitution for trifluoromethylated styrenes

• Mark:

  Scheme 2

• Associated context:

  We have shown that the direction of transformations depends dramatically on the nature of aromatic substituent of initial substrate: styrenes bearing an electron-withdrawing group are converted into trifluoromethy-lated enamines (secondary amines) and/or azomethines (primary amines) or heterocycles (binucleophiles) while their analogs bearing electron-donor group in benzene ring give unexpected products of nucleophilic C–F bond cleavage (primary or secondary amines) or fragmentation (binucleophiles) (Scheme 2).