Mechanism of the reaction of EWG-substituted styrenes with N-nucleophiles

July 23, 2024

• Title:       

  Mechanism of the reaction of EWG-substituted styrenes with N-nucleophiles

• Image Source:

  Mechanistic study of multi-step nucleophilic substitution for trifluoromethylated styrenes

• Mark:

  Scheme 4

• Associated context:

  The first step of the sequence is the perpendicular attack of amine on the double bond to form carbanion Y. After 608 turns the conformation for anti-elimination is formed. Finally, it gives the alkene with retention of configuration (Scheme 4).