The reactions of amines with EDG-substituted styrenes

July 23, 2024

• Title:       

  The reactions of amines with EDG-substituted styrenes

• Image Source:

  Mechanistic study of multi-step nucleophilic substitution for trifluoromethylated styrenes

• Mark:

  Scheme 5

• Associated context:

  Scheme 5 shows the stepwise reaction between styrene 1c and nitrogen nucleophiles, including the proposed principal intermediates 5–7. The results obtained suggest a stepwise mechanism (E–Ad) including the formation of acetylenic derivative 5 as a key intermediate.