By-products in 7 and 2

July 24, 2024

• Title:       

  By-products in 7 and 2

• Image Source:

  Development of a practical route for the manufacture of N-[5-(3-lmidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]acetamide

• Mark:

  Figure 1

• Associated context:

  A rapid temperature study and optimization of the amount of sodium methylsulfinate showed that the formation of the bis-sulfonylated product 8 was the major process impurity  (see Figure 1).