Inhibition of KLK3 by Z-Pro-Prolinal. (A) Progress curve of product formation in different concentrations of inhibitor

July 26, 2024

• Title:       

  Inhibition of KLK3 by Z-Pro-Prolinal. (A) Progress curve of product formation in different concentrations of inhibitor

• Image Source:

  Substrate specificity and inhibition of human kallikrein-related peptidase 3 (KLK3 or PSA) activated with sodium citrate and glycosaminoglycans

• Mark:

  Fig. 7

• Associated context:

  This observation was confirmed by the reversible slow-binding inhibition of KLK3 by the commercially available prolyl-oligopeptidase inhibitor Z-Pro-Prolinal [32] (Fig. 7), with Ki = 40  μM and k4 = 0.05 min-1 and 0.03 min-1.