Copper-catalyzed aerobic oxidative thiocyanation of arylboronic acids

July 29, 2024

• Title:       

  Copper-catalyzed aerobic oxidative thiocyanation of arylboronic acids

• Image Source:

  A mild copper-catalyzed aerobic oxidative thiocyanation of arylboronic acids with TMSNCS

• Mark:

  Scheme 1

• Associated context:

  Previously, we have described a novel method for the synthesis of aryl thiocyanates from arylboronic acids and KSCN (CAS 333-20-0) by Cu(OAc)₂-catalyzed aerobic oxidative aryl C-S bond formation (Scheme 1, A). In this work, we proposed a new method for the preparation of aryl thiocyanates from arylboronic acids by using trimethylsilylisothiocyanate (TMSNCS) as a thiocyantion reagent (Scheme 1, B).