Synthesis of iminonitriles by oxidative three-component Strecker reaction of aldehydes, amines, and TMSCN

July 31, 2024

• Title:       

  Synthesis of iminonitriles by oxidative three-component Strecker reaction of aldehydes, amines, and TMSCN

• Image Source:

  Synthesis of iminonitriles by oxone/tbab-mediated one-pot oxidative three-component strecker reaction

• Mark:

  Scheme 1

• Associated context:

  In 2008, our group reported a one-pot oxidative three-component Strecker reaction for the synthesis of α-iminonitriles from aldehydes, amines, and trimethylsilyl cyanide (TMSCN) using o-iodoxybenzoic acid (IBX)4 as oxidant assisted by tetra-n-butylammoni-um bromide (TBAB) (Scheme 1, eq 1).