(Top) HPNP Cleavage by Nanozyme Mechanism and (Bottom) Metal Chelating Thiols Used in This Work

August 12, 2024

• Title:       

  (Top) HPNP Cleavage by Nanozyme Mechanism  and (Bottom) Metal Chelating Thiols Used in This Work

• Image Source:

  Efficient phosphodiester cleaving nanozymes resulting from multivalency and local medium polarity control

• Mark:

  Chart 1

• Associated context:

  In this communication, we report how by taking full advantage of the modular structure of an enzyme, which allows the easy modification of the organic coating monolayer,  we were able to obtain a nanosystem capable of accelerating in water the cleavage of an RNA model substrate (2-hydroxypropyl-p-nitrophenyl phosphate, HPNP, Chart 1) more efficiently than any other artificial hydrolytic agent so far reported in this solvent.