A Plausible Mechanism for the N-Alkylation of Aqueous Ammonia with an Alcohol

August 15, 2024

• Title:       

  A Plausible Mechanism for the N-Alkylation of Aqueous Ammonia (CAS 7664-41-7) with an Alcohol

• Image Source:

  Multialkylation of aqueous ammonia with alcohols catalyzed by water-soluble CpIr-ammine complexes

• Mark:

  Scheme 1

• Associated context:

  Based on the mechanisms proposed for the Cp*Ir-catalyzed N-alkylation of amines, 10 a plausible mechanism for the first monoalkylation cycle transiently affording primary amine is depicted in Scheme 1. The second and third N-alkylations to produce secondary and tertiary amines, respectively, would proceed through similar sequential processes.