Enzyme selectivity of compound 3

August 16, 2024

• Title:       

  Enzyme selectivity of compound 3

• Image Source:

  Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors

• Mark:

  Table 7

• Associated context:

  As shown in Table 7, analog 3 exhibited exquisite selectivity over other kinases. It was at least 200-fold  selective over Tec family kinases and over 55-fold selective against other kinases tested. In addition, 3 showed  ATP competitive kinetics.