Single dose pharmacokinetic parameters of compound 3 in mice

August 16, 2024

• Title:       

  Single dose pharmacokinetic parameters of compound 3 in mice

• Image Source:

  Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors

• Mark:

  Table 8

• Associated context:

  Prior to assessing activity in vivo, the pharmacokinetic profile of 3 was determined in mice (Table 8). Single iv and oral doses of 3 were administered. Concentrations of 3 were determined in plasma using an LC/MS  assay.