Poly(5-fluorocytidylic acid)
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Add time:09/01/2019 Source:sciencedirect.com
Poly (5-fluorocytidylic acid) [poly(f5C)] has been prepared by the polymerisation of 5-fluorocytidine diphosphate with polynucleotide phosphorylase. The polymer forms a 1:1 hydrid with poly(I) and this hybrid is a good inducer of interferon. From a comparison of the melting temperatures of hybrids of poly(I) and poly(5-halogenated cytidylic acids) [poly(x5 C)], there appears to be a linear relationship between the Tm and the size of the substituent x.
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