Oligonucleotides containing modified bases. I. Inhibition of DNA and RNA polymerases by partially thiolated oligocytidylic acids
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Add time:09/03/2019 Source:sciencedirect.com
A series of oligomers of cytidylic acid were prepared and partially (6–9% of the bases) thiolated in the 5 positions. The modified oligomers showed increasing inhibition with increasing chain length of both the DNA polymerase-α from regenerating rat liver and the DNA-dependent RNA polymerase of E.coli, but the minimum chain length for observable inhibitory activity was 5 nucleotide units for the DNA polymerase-α and 16 units for the RNA polymerase.
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